Retinal Microcirculation in Predicting Diabetic Nephropathy in Type 2 Diabetic Patients without Retinopathy

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dc.authoridTEKIN, KEMAL/0000-0002-7461-6129
dc.authoridTURGUT, FARUK/0000-0003-1910-7433
dc.contributor.authorCankurtaran, Veysel
dc.contributor.authorInanc, Merve
dc.contributor.authorTekin, Kemal
dc.contributor.authorTurgut, Faruk
dc.date.accessioned2024-09-18T20:15:08Z
dc.date.available2024-09-18T20:15:08Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To evaluate retinal thicknesses and retinal microcirculation in healthy controls and in diabetic patients with or without microalbuminuria. Methods: Eighty-six diabetic patients without diabetic retinopathy (DR) (44 normoalbuminuric, 42 microalbuminuric) and 51 healthy controls were enrolled in this cross-sectional, prospective study. Optical coherence tomography (OCT) and OCT angiography (OCTA) were performed. Correlations between OCTA parameters with mean urinary albumin levels were evaluated. Results: The mean vessel densities of superficial capillary plexus (SCP), whole disc, and peripapillary area were significantly decreased in patients with microalbuminuria compared to patients with normoalbuminuria and controls (p < 0.05 for all). The mean vessel density of deep capillary plexus was significantly reduced in patients with microalbuminuria compared to controls (p < 0.05 for all). There were no significant differences in retinal thickness between groups (p > 0.05). Both duration of diabetes and urinary albumin levels were significantly and moderately correlated with mean vessel density of whole SCP in diabetic patients (r = 0.330, p = 0.021; r = 0.356, p = 0.017, respectively). Conclusion: Diabetic eyes without clinically detectable DR show impaired retinal microcirculation. Microalbuminuria is associated with alterations of retinal microcirculation in diabetic patients without DR. Evaluation of retinal microcirculation is likely useful for detecting early changes related to microvascular complications in type 2 diabetic patients.en_US
dc.identifier.doi10.1159/000504943
dc.identifier.endpage279en_US
dc.identifier.issn0030-3755
dc.identifier.issn1423-0267
dc.identifier.issue4en_US
dc.identifier.pmid31775153en_US
dc.identifier.scopus2-s2.0-85088495256en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://doi.org/10.1159/000504943
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9469
dc.identifier.volume243en_US
dc.identifier.wosWOS:000600997600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOphthalmologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectDiabetic retinopathyen_US
dc.subjectDiabetic nephropathyen_US
dc.subjectMicroalbuminuriaen_US
dc.subjectOptical coherence tomography angiographyen_US
dc.titleRetinal Microcirculation in Predicting Diabetic Nephropathy in Type 2 Diabetic Patients without Retinopathyen_US
dc.typeArticleen_US

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