Effect of Radioactive Iodine Therapy on Lacrimal Gland Functions in Patients With Hyperthyroidism

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dc.authoridUstun, Ihsan/0000-0002-5848-1586
dc.contributor.authorAydogan, Fusun
dc.contributor.authorTuzcu, Esra Ayhan
dc.contributor.authorAydogan, Akin
dc.contributor.authorAkkucuk, Seckin
dc.contributor.authorCoskun, Mesut
dc.contributor.authorUstun, Ihsan
dc.contributor.authorGokce, Cumali
dc.date.accessioned2024-09-18T20:59:18Z
dc.date.available2024-09-18T20:59:18Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Radioactive iodine (RAI) therapy is preferred in the treatment of hyperthyroidism because of its effectiveness, noninvasiveness, and low costs. I-131 has been detected in extrathyroidal tissues, such as in gastric mucosa, salivary glands, and lacrimal glands. To the best of our knowledge, there is no publication concerning the effects of RAI therapy for hyperthyroidism on tear production. In the present study, we evaluated whether or not the lacrimal glands are affected after RAI therapy when compared with pretreatment period. Methods The Schirmer and tear break-up time (TBUT) tests were used to assess 32 eyes of 16 patients with conditions that were diagnosed as hyperthyroidism before and at 3 and 6 months after RAI treatment. In addition, pretreatment values of patients were compared with that of controls. It was evaluated whether or not a correlation exists between the results and the dose or iodine uptake values. Results There was no significant difference between pretreatment values of Schirmer and TBUT tests obtained in the patient group and those of the control group (P > 0.05). In the patient group, there was a significant difference between the posttreatment and pretreatment values (P < 0.05). There was a positive correlation between uptake values obtained at 24 hours and the values obtained by TBUT and Schirmer tests on both eyes at 3 and 6 months. At 6 months, the uptake value at 24 hours was 28.83 +/- 60 for both eyes in patients with TBUT test values less than 10, whereas it was 39.25 +/- 7.88 for the right eye and 39.00 +/- 6.85 for the left eyes in patients with TBUT test values greater than 10. The difference was statistically significant (P < 0.05). Conclusions In our study, we concluded that the decrease in mucin and aqueous production occurs due to affected lacrimal glands by RAI therapy; however, this effect is not dose dependent.en_US
dc.identifier.doi10.1097/RLU.0000000000000308
dc.identifier.endpage318en_US
dc.identifier.issn0363-9762
dc.identifier.issn1536-0229
dc.identifier.issue4en_US
dc.identifier.pmid24300361en_US
dc.identifier.scopus2-s2.0-84896404918en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage315en_US
dc.identifier.urihttps://doi.org/10.1097/RLU.0000000000000308
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12504
dc.identifier.volume39en_US
dc.identifier.wosWOS:000333022300015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofClinical Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttearen_US
dc.subjectiodine uptakeen_US
dc.subjecthyperthyroidismen_US
dc.subjectlacrimal glanden_US
dc.subjectradioactive iodineen_US
dc.titleEffect of Radioactive Iodine Therapy on Lacrimal Gland Functions in Patients With Hyperthyroidismen_US
dc.typeArticleen_US

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