Very high levels of C-reactive protein should alert the clinician to the development of acute chest syndrome in sickle cell patients

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dc.contributor.authorAcipayam, Can
dc.contributor.authorKaya, Sadik
dc.contributor.authorHelvaci, Mehmet Rami
dc.contributor.authorIlhan, Gul
dc.contributor.authorOktay, Gonul
dc.date.accessioned2024-09-18T20:57:01Z
dc.date.available2024-09-18T20:57:01Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Acute chest syndrome (ACS) is associated with both inflammation and tissue ischemia. C-reactive protein (CRP) is a marker of systemic inflammation. The aim of this study was to determine if a relationship exists between CRP and severe ACS. Methods: Forty-three patients with painful crises (range: 4-18 years, mean: 11.4 years) hospitalized between 2012 and 2014, consisting of 23 patients with ACS and 20 patients without ACS (uncomplicated vaso-occlusive crisis) were recruited into this study. Retrospective data were obtained directly from inpatient medical records. ACS was defined as a new pulmonary infiltrate on chest radiograph after admission and before discharge. CRP was measured using a BN II Nephelometer. Results: Mean length of hospital stay of ACS patients was 9.9 days (range 7-18 days) while that of patients without ACS was 5.2 days (range 2-10 days), (p=0.001). In 91% of the ACS cases, ACS developed within the first 72 hours, while the remaining 9% cases were admitted for vaso-occlusive crises but subsequently developed ACS during their hospital stay on the 5th to 7th days. CRP levels on admission were significantly higher in patients with ACS than those without ACS (p=0.001). C onclusion: We investigated CRP in relation to ACS in children with sickle cell disease (SCD). Elevated CRP was determined in all ACS patients with SCD. CRP may be a superior diagnostic marker and herald severe ACS in individuals with SCD.en_US
dc.identifier.doi10.5742/MEWFM.2014.92531
dc.identifier.endpage9en_US
dc.identifier.issn1839-0188
dc.identifier.issn1839-0196
dc.identifier.issue6en_US
dc.identifier.startpage4en_US
dc.identifier.urihttps://doi.org/10.5742/MEWFM.2014.92531
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12246
dc.identifier.volume12en_US
dc.identifier.wosWOS:000421852400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMedi+World Inten_US
dc.relation.ispartofWorld Family Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSickle cell diseasesen_US
dc.subjectAcute chest syndromeen_US
dc.subjectC-reactive proteinen_US
dc.titleVery high levels of C-reactive protein should alert the clinician to the development of acute chest syndrome in sickle cell patientsen_US
dc.typeArticleen_US

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