Turkish Plants, Including Quercetin and Oenothein B, Inhibit the HIV-1 Release and Accelerate Cell Apoptosis

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dc.authoridSugimura, Koji/0000-0002-4507-5749
dc.contributor.authorTahara, Yurika
dc.contributor.authorFujita, Mikako
dc.contributor.authorZhang, Tianli
dc.contributor.authorWang, Dongxing
dc.contributor.authorTateishi, Hiroshi
dc.contributor.authorTogami, Akihiro
dc.contributor.authorNyame, Perpetual
dc.date.accessioned2024-09-18T20:26:51Z
dc.date.available2024-09-18T20:26:51Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe introduction of combined anti-retroviral therapy (cART) in 1996, along with a continual breakthrough in anti-human immunodeficiency virus-1 (HIV-1) drugs, has improved the life expectancies of HIV-1-infected individuals. However, the incidence of drug-resistant viruses between individuals undergoing cART and treatment-naive individuals is a common challenge. Therefore, there is a requirement to explore potential drug targets by considering various stages of the viral life cycle. For instance, the late stage, or viral release stage, remains uninvestigated extensively in antiviral drug discovery. In this study, we prepared a natural plant library and selected candidate plant extracts that inhibited HIV-1 release based on our laboratory-established screening system. The plant extracts from Epilobium hirsutum L. and Chamerion angustifolium (L.) Holub, belonging to the family Onagraceae, decreased HIV-1 release and accelerated the apoptosis in HIV-1-infected T cells but not uninfected T cells. A flavonol glycoside quercetin with oenothein B in Onagraceae reduced HIV-1 release in HIV-1-infected T cells. Moreover, extracts from Chamerion angustifolium (L.) Holub and Senna alexandrina Mill. inhibited the infectivity of progeny viruses. Together, these results suggest that C. angustifolium (L.) Holub contains quercetin with oenothein B that synergistically blocks viral replication and kills infected cells via an apoptotic pathway. Consequently, the plant extracts from the plant library of Turkey might be suitable candidates for developing novel anti-retroviral drugs that target the late phase of the HIV-1 life cycle.en_US
dc.description.sponsorshipAMED [21fk0410026h0001]; JSPS KAKENHI [19K23802]; Young Investigator Award at the Joint Research Center for Human Retrovirus Infection, Kumamoto University; Shinnihon Foundation of Advanced Medical Treatment Research; Japan Society for the Promotion of Science [20H03365]; Bilateral Joint Research Project from the Japan Society for the Promotion of Science [16039901-00867]en_US
dc.description.sponsorshipWe would like to thank Dr. E. Freed for providing plasmids, and Dr. Jacques Corbeil for providing the CEM-GFP cells.This work was supported by AMED (21fk0410026h0001) to K.M., JSPS KAKENHI (19K23802) to H.T., and the Young Investigator Award at the Joint Research Center for Human Retrovirus Infection, Kumamoto University to K.M., and The Shinnihon Foundation of Advanced Medical Treatment Research to K.M., and Bilateral Joint Research Project from the Japan Society for the Promotion of Science (16039901-00867) to M.O., and a Grant in Aid for Scientific Research (B) from the Japan Society for the Promotion of Science (20H03365) to M.F.en_US
dc.identifier.endpage1547en_US
dc.identifier.issn0918-6158
dc.identifier.issn1347-5215
dc.identifier.issue11en_US
dc.identifier.pmid37914356en_US
dc.identifier.scopus2-s2.0-85175769892en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1535en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10569
dc.identifier.volume46en_US
dc.identifier.wosWOS:001099750800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPharmaceutical Soc Japanen_US
dc.relation.ispartofBiological & Pharmaceutical Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthuman immunodeficiency virus-1 (HIV-1)en_US
dc.subjectquercetinen_US
dc.subjectoenothein Ben_US
dc.subjectOnagraceaeen_US
dc.subjectflavonolen_US
dc.subjectapoptosisen_US
dc.titleTurkish Plants, Including Quercetin and Oenothein B, Inhibit the HIV-1 Release and Accelerate Cell Apoptosisen_US
dc.typeArticleen_US

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