Calcium fructoborate regulate colon cancer (Caco-2) cytotoxicity through modulation of apoptosis

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dc.authoridKISACAM, Mehmet Ali/0000-0003-0521-9434
dc.contributor.authorKisacam, Mehmet A.
dc.contributor.authorAmbarcioglu, Pinar
dc.contributor.authorYakan, Akin
dc.date.accessioned2024-09-18T20:02:47Z
dc.date.available2024-09-18T20:02:47Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSugar-borate esters have recently been reported to have anti-cancer potential. Among the sugar-borate esters, calcium fructoborate (CaFB) possesses beneficial effects on human health. Despite the beneficial effects of CaFB, there is a lack of knowledge about their mode of action in cancer. The potential cytotoxic effects of CaFB were investigated on colon cancer cells (Caco-2). The mode of action was determined through the evaluation of Fyn and Hck expression levels together with Bcl-2, Bax, and PI3K/Akt pathway proteins. CaFB treatment was found to be most effective on Caco-2 cells at 10 mM concentration for 24 h. Decreased Bcl-2 levels and increased Bax levels at 10 mM were evaluated as an indicator of apoptotic effects of CaFB. Akt, p70S6K, and 4EBP1 levels, in general, tend to decrease following CaFB, while PTEN and TSC2 levels have been found to increase. Furthermore, CaFB upregulated Hck expression and downregulated Fyn expression. In conclusion, our results indicated that CaFB treatment at 10 mM concentration, the IC50 dose found in our study, might prevent colon cancer cell proliferation both by inducing apoptosis and presumably by activating autophagy.en_US
dc.description.sponsorshipMustafa Kemal University Research Fund [20]en_US
dc.description.sponsorshipMustafa Kemal University Research Fund, Grant/Award Number: 20.GAP.009en_US
dc.identifier.doi10.1002/jbt.23021
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue5en_US
dc.identifier.pmid35174920en_US
dc.identifier.scopus2-s2.0-85124736168en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.23021
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8026
dc.identifier.volume36en_US
dc.identifier.wosWOS:000756621000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectautophagyen_US
dc.subjectcalcium Ffructoborateen_US
dc.subjectcellular apoptosisen_US
dc.subjectcolon canceren_US
dc.subjectPI3Ken_US
dc.subjectAkten_US
dc.subjectSrc kinaseen_US
dc.titleCalcium fructoborate regulate colon cancer (Caco-2) cytotoxicity through modulation of apoptosisen_US
dc.typeArticleen_US

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