Effects of tadalafil on ischemia/reperfusion injury in rat brain

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dc.authoridMEYDAN, SEDAT/0000-0002-1393-3235
dc.authoridUlutas, Kemal Turker/0000-0003-2852-0449
dc.contributor.authorAltas, Murat
dc.contributor.authorAras, M.
dc.contributor.authorMeydan, S.
dc.contributor.authorNacar, E.
dc.contributor.authorUlutas, K. T.
dc.contributor.authorSerarslan, Y.
dc.contributor.authorYilmaz, N.
dc.date.accessioned2024-09-18T20:59:15Z
dc.date.available2024-09-18T20:59:15Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCerebral ischemia-reperfusion (I/R) injury is caused by lack of blood supply to the brain. The accumulation of toxic products such as reactive oxygen species (ROS) occurs on reperfusion, when the occlusion is removed. The resulting oxidative stress results in the initiation of pathways leading to necrotic and apoptotic cell death. Tadalafil (TAD) prevents the accumulation of ROS and increases antioxidant cellular protective mechanisms. The aim of this study was to investigate the effect of TAD treatment against short-term global brain I/R injury in rats. The study was carried out on 30 Wistar-albino rats, which were divided into three groups including a control group (n = 10), an I/R group (n = 10) and an I/R + TAD group (n = 10) (2 mg/kg/day for 4 days before ischemia). At the end of the experiment, tissue samples were collected for both biochemical and histopathological analyses. Malondialdehyde was significantly lower in the TAD-administered group (9.06 +/- A 0.15) than in the I/R group (p < 0.05). However, no significant difference was observed in nitric oxide levels in the TAD-administered group compared to the I/R group. The mean superoxide dismutase level was significantly higher in the I/R-TAD group than the I/R group. There was no statistically significant difference in glutathione peroxidase levels in I/R + TAD group compared to I/R group. Histopathologically, TAD-administered group provided significant morphological improvement compared to the I/R group. We concluded that TAD prevented I/R-induced neurotoxicity as shown by obtained biochemical and histopathological findings.en_US
dc.identifier.doi10.1007/s13760-013-0234-2
dc.identifier.endpage40en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue1en_US
dc.identifier.pmid23918637en_US
dc.identifier.scopus2-s2.0-84896839071en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-013-0234-2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12481
dc.identifier.volume114en_US
dc.identifier.wosWOS:000332453800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTadalafilen_US
dc.subjectBrainen_US
dc.subjectIschemia/reperfusionen_US
dc.titleEffects of tadalafil on ischemia/reperfusion injury in rat brainen_US
dc.typeArticleen_US

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