Decreased Paraoxonase 1, Arylesterase Enzyme Activity, and Enhanced Oxidative Stress in Patients with Mitral and Aortic Valve Insufficiency

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dc.authoridaydin, ozgur/0000-0002-6123-6186
dc.contributor.authorYilmaz, Necat
dc.contributor.authorSimsek, Nevin
dc.contributor.authorAydin, Ozgur
dc.contributor.authorYardan, Emirivin
dc.contributor.authorAslan, Sakir
dc.contributor.authorEren, Esin
dc.contributor.authorYegin, Aysenur
dc.date.accessioned2024-09-18T20:26:35Z
dc.date.available2024-09-18T20:26:35Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Oxidative stress is reportedly associated with several cardiovascular diseases. The antioxidant ability of high density lipoprotein (HDL) is, at least in part, attributable to the pleiotropic serum paraoxonase (PON1). The aim of the study was to investigate the body oxidant/antioxidant balance in patients with mitral regurgitation (MR) and aortic regurgitation (AR) to get new points of view for the underlying oxidative mechanisms. Methods: Oxidative stress index (OSI), total oxidant status (TOS), and total antioxidant status (TAS) were examined in addition to the PON1 and arylesterase (ARE) enzyme activities in fifty-six patients and thirty-seven healthy control subjects. Results: Serum PON1 and ARE enzyme activities were statistically significantly reduced in heart valve disease (HVD) patients (p = 0.0005 and p < 0.0001, respectively), whereas TOS and OSI levels were found to be significantly higher (p = 0.0021 and p < 0.0001, respectively). Conclusions: Serum PON1 activity is reduced in patients with HVD, caused by elevated oxidative stress and disturbances of heart valve metabolism. The findings from this novel detailed approach, implicate an inflammatory/oxidative stress process in the pathogenesis of the valve's presentation associated with the HVD. The strength of the significance in differences encourage us to propose that the role of oxidative stress in HVD pathogenesis is very prominent, and oxidative stress markers are potential ancillary tests to evaluate the state of the disease.en_US
dc.identifier.doi10.7754/Clin.Lab.2012.120629
dc.identifier.endpage604en_US
dc.identifier.issn1433-6510
dc.identifier.issue5-6en_US
dc.identifier.pmid23865359en_US
dc.identifier.scopus2-s2.0-84879399926en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage597en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2012.120629
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10418
dc.identifier.volume59en_US
dc.identifier.wosWOS:000328913200018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectheart valve diseaseen_US
dc.subjectoxidanten_US
dc.subjectantioxidanten_US
dc.subjectparaoxonaseen_US
dc.subjectarylesteraseen_US
dc.subjectoxidative stressen_US
dc.titleDecreased Paraoxonase 1, Arylesterase Enzyme Activity, and Enhanced Oxidative Stress in Patients with Mitral and Aortic Valve Insufficiencyen_US
dc.typeArticleen_US

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