Chemical composition, antimicrobial and antibiofilm efficacy of C. limon and L. angustifolia EOs and of their mixtures against Staphylococcus epidermidis clinical strains

Basit Öğe Kaydı
dc.authoridMoldovan, Zenovia/0000-0002-0320-9921
dc.authoridKaya, Durmus Alpaslan/0000-0003-3544-9214
dc.authoridChifiriuc, Mariana Carmen/0000-0001-6098-1857
dc.contributor.authorDanila, Elena
dc.contributor.authorMoldovan, Zenovia
dc.contributor.authorPopa, Marcela
dc.contributor.authorChifiriuc, Mariana Carmen
dc.contributor.authorKaya, Alpaslan Durmus
dc.contributor.authorKaya, Madalina Albu
dc.date.accessioned2024-09-18T20:19:53Z
dc.date.available2024-09-18T20:19:53Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractStaphylococcus epidermidis is a Gram-positive resident of the human skin, which in certain conditions, can turn into an opportunistic pathogen, being one of the most frequent agents of nosocomial infections, particularly of those associated with indwelling medical devices. The aim of this study was to evaluate the antimicrobial and antibiofilm activity of two essential oils (EOs) to be used alone or in combination as natural alternatives to currently available antibiotics, for treating S. epidermidis infections or preventing the contamination and further development of S. epidermidis biofilm on viable tissues or medical devices. For this purpose C. Limon and L. angustifolia EOs were obtained both by hydrodistillation and microwave-assisted extraction and analyzed by GC MS. The compositions of EOs as a function of the extraction procedure were compared and discussed. Each of the two extraction techniques was more effective in the extraction of different components of the EOs. In the case of C. limon EOs, terpinen-4-ol, alpha-terpineol and linalool, not found in the microwave assisted extract, are obtained by classical hydrodistillation (being compounds of high polarity) while less polar compounds (alpha-pinene, beta-pinene, limonene, gamma-terpinene) are drawn into higher percentage through the microwave-assisted procedure. In the case of L. angustifolia EOs, a higher percentage of compounds with high polarity (such as linalool) is extracted by classical hydrodistillation while the compounds with lower polarity, such as acetates (linalyl acetate and neryl acetate) are extracted in higher proportion by the microwave-assisted extraction method. The antibacterial and antibiofilm effects of the EOs and of their mixtures were tested towards five S. epidermidis clinical strains and their biological activity was correlated with the oils composition. The most active composition was represented by the binary mixture (1:1) of the EOs obtained by hydrodistillation, containing terpene alcohols (such linalool) and D-limonene, which exhibited the lowest minimum inhibitory concentration (3.9 mu g/mL) and minimum biofilm eradicating concentration (0.97-7.81 mu g/mL), against all tested S. epidermidis strains. Other minor constituents, such as terpinen-4-ol, alpha-terpineol, linalyl acetate, neryl acetate, geranyl acetate and a-pinene could be potentiated in presence of limonene and could be responsible for the high antimicrobial activity of these EOs mixture.en_US
dc.identifier.doi10.1016/j.indcrop.2018.06.019
dc.identifier.endpage492en_US
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.scopus2-s2.0-85048337236en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage483en_US
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2018.06.019
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9923
dc.identifier.volume122en_US
dc.identifier.wosWOS:000442067300057en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofIndustrial Crops and Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEssential oilsen_US
dc.subjectCombinationsen_US
dc.subjectStaphylococcus epidermidisen_US
dc.subjectAntimicrobial activityen_US
dc.titleChemical composition, antimicrobial and antibiofilm efficacy of C. limon and L. angustifolia EOs and of their mixtures against Staphylococcus epidermidis clinical strainsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
575.61 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu