Effects of Tempol on Epileptic Activity in Picrotoxin-Induced Epilepsy in Rats

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dc.contributor.authorPinar, Neslihan
dc.date.accessioned2024-09-18T20:19:48Z
dc.date.available2024-09-18T20:19:48Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Epilepsy is a common neurological disease, although its etiology and pathophysiology are not yet fully understood. Oxidative stress plays a key role in the pathogenesis of many neurological diseases, including epilepsy, and there have been many studies reporting that antiepileptic medicines with neuroprotective and antioxidant activity inhibit free oxygen radicals. This study evaluates the effects of tempol on epileptic activity through behavioral parameters in acute picrotoxin (Ptx) models. Materials and Methods: This experimental study was conducted on 42 adult male Wistar Albino rats weighing 450-500 g. Ptx (2.5 mg/kg) was injected i.p. as a single dose and observed for one hour to establish the acute Ptx model. Following injection, the animals were observed for 30 min in glass observation cages measuring 35 cm x 35 cm x 35 cm. Results: In picrotoxin-induced epilepsy, the total number of seizures and the total duration of seizures were decreased significantly with Ptx + tempol 100 mg/kg and Ptx + Tempol 150 mg/kg. The seizure phases were reduced significantly by Ptx + tempol 150 mg/kg (P < 0.05). Conclusion: Tempol 100 mg/kg and tempol 150 mg/kg are found to be effective in epilepsy models caused by Ptx, with tempol 150 mg/kg found especially to be more effective.en_US
dc.identifier.doi10.4103/0028-3886.314542
dc.identifier.endpage429en_US
dc.identifier.issn0028-3886
dc.identifier.issn1998-4022
dc.identifier.issue2en_US
dc.identifier.pmid33904467en_US
dc.identifier.scopus2-s2.0-85105380238en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage426en_US
dc.identifier.urihttps://doi.org/10.4103/0028-3886.314542
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9860
dc.identifier.volume69en_US
dc.identifier.wosWOS:000646219200038en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNeurology Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpilepsyen_US
dc.subjectpicrotoxinen_US
dc.subjecttempol Key Messageen_US
dc.subjectEpilepsy is a common neurological diseaseen_US
dc.subjectthe etiology and pathophysiology of which are not yet fully understooden_US
dc.subjectOxidative stress plays a role in the pathogenesis of epilepsyen_US
dc.subjectPretreatment with Tempol reduces Ptx induced tonic-clonic seizures through its anti-inflammatory and antioxidant effectsen_US
dc.subjectFurther studies are needed to investigate the mechanisms behind the antiepileptic effect of tempolen_US
dc.titleEffects of Tempol on Epileptic Activity in Picrotoxin-Induced Epilepsy in Ratsen_US
dc.typeArticleen_US

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