The Beneficial Effects of Tadalafil on Renal Ischemia-Reperfusion Injury in Rats

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dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.authoridBagriyanik, Husnu Alper/0000-0003-4064-7637
dc.contributor.authorGuzeloglu, Mehmet
dc.contributor.authorYalcinkaya, Fatih
dc.contributor.authorAtmaca, Soner
dc.contributor.authorBagriyanik, Alper
dc.contributor.authorOktar, Suleyman
dc.contributor.authorYuksel, Oguz
dc.contributor.authorFansa, Iyad
dc.date.accessioned2024-09-18T20:28:17Z
dc.date.available2024-09-18T20:28:17Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAcute renal failure due to ischemia-reperfusion (I/R) injury is a common complication in cardiovascular surgery. We determined the influence of tadalafil on renal injury in a renal I/R model in rats. For this purpose, 21 male Wistar albino rats were separated into 3 groups: sham, placebo and tadalafil. A right nephrectomy was performed, and the left renal pedicles were occluded for 60 min and reperfused for 60 min in the placebo and tadalafil groups. A single dose of tadalafil (10 mg/kg) through an orogastric tube was administered to the tadalafil group. Tubular atrophy with acute inflammation in renal histology, total oxidant status (TOS) and total antioxidant status (TAS) were determined in tissue homogenates. Compared to the tadalafil group, tubular atrophy and acute inflammation was significant in the placebo group. TAS levels were significantly higher in the tadalafil group compared to the placebo (p = 0.01) and sham groups (p = 0.04). While TOS levels were significantly higher in the placebo group (p = 0.03), tadalafil did not significantly alter the TOS levels. The beneficial effects of tadalafil can be attributed to its protective effects on renal tubular cells and inhibition of leukocyte infiltration in renal tissue. We think that tadalafil treatment has an important role in reducing renal injury resulting from renal I/R. Copyright (c) 2010 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000321927
dc.identifier.endpage203en_US
dc.identifier.issn0042-1138
dc.identifier.issn1423-0399
dc.identifier.issue2en_US
dc.identifier.pmid21160160en_US
dc.identifier.scopus2-s2.0-79952989004en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://doi.org/10.1159/000321927
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10825
dc.identifier.volume86en_US
dc.identifier.wosWOS:000288878500012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKidneyen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectLeukocyte infiltrationen_US
dc.subjectTadalafilen_US
dc.subjectRatsen_US
dc.titleThe Beneficial Effects of Tadalafil on Renal Ischemia-Reperfusion Injury in Ratsen_US
dc.typeArticleen_US

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