Antibacterial activity of propolis against MRSA and synergism with topical mupirocin

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dc.contributor.authorOnlen, Yusuf
dc.contributor.authorDuran, Nizami
dc.contributor.authorAtik, Esin
dc.contributor.authorSavas, Lutfu
dc.contributor.authorAltug, Enes
dc.contributor.authorYakan, Selvinaz
dc.contributor.authorAslantas, Ozkan
dc.date.accessioned2024-09-18T21:05:08Z
dc.date.available2024-09-18T21:05:08Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: The aim of the present study was to investigate the activity of the propolis and its combinations with mupirocin against methicillin-resistant Staphylococcus aureus (MRSA) in nasal carriage. Methods: This study was carried out between June and August 2005. To infect nares of the rabbits, MRSA ( ATCC 33591) strain was used. Minimum inhibitory concentration was determined according to National Committee for Clinical Laboratory Standards. Each inoculum was prepared in the same medium at a density adjusted to a 0.5 McFarland turbidity standard (10(5) colony- forming units [cfu]/ mL) and diluted 1: 100 for the broth microdilution procedure. Ten microliters (10 mu L) (10(5) cfu/mL) of the bacterial suspension containing approximately 1000 cfu of MRSA was administered with sterile microsyringe through both nostrils of each rabbit. Ninety-six ( 96) hours after inoculation, the presence of infection was confirmed by using bacterial cultures. Twenty-six young New Zealand rabbits were randomly divided into 4 groups. Each treatment group ( 1, 2, and 3) included 7 rabbits and control group ( group 4) included 5 rabbits. Group 1 was treated with topical mupirocin + ethanolic extract of propolis drops, group 2 received topical mupirocin, group 3 was administered ethanolic extract of propolis drops, and the control group ( group 4) was only treated with phosphate-buffered solution drops for 7 days. At the end of study, nasal cultures and smears were obtained for bacterial count and cytologic examination. Results: The colony numbers of bacteria in group 1 were determined to be significantly lower than in group 2 (p= 0.0001), group 3 (p = 0.0001), and group 4 ( p = 0.0001). The mean bacterial cell counts of groups 1- 4 were 360.2 +/- 52.4 cfu/ mL, 4120.6 +/- 860.4 cfu/ mL, 5980.8 +/- 1240.6 cfu/ mL, and 11500.0 +/- 2568.4 cfu/ mL, respectively. Mupirocin + propolis administration ( group 1) resulted in a significant reduction in the polymorphonuclear leukocyte (PMNL) count in the mucous membranes of rabbits compared with the other treatment groups ( p < 0.05). Conclusions: Propolis addition to mupirocin regimen was found to result in more profound reduction in bacterial cell count and inflammatory response compared with the rest of the treatment modalities.en_US
dc.identifier.doi10.1089/acm.2007.7021
dc.identifier.endpage718en_US
dc.identifier.issn1075-5535
dc.identifier.issn1557-7708
dc.identifier.issue7en_US
dc.identifier.pmid17931063en_US
dc.identifier.scopus2-s2.0-35348882897en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage713en_US
dc.identifier.urihttps://doi.org/10.1089/acm.2007.7021
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13395
dc.identifier.volume13en_US
dc.identifier.wosWOS:000250191300007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal of Alternative and Complementary Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResistant Staphylococcus-Aureusen_US
dc.subjectNasal Carriageen_US
dc.subjectBiological-Propertiesen_US
dc.subjectIntranasal Mupirocinen_US
dc.subjectEpidemiologyen_US
dc.subjectInfectionsen_US
dc.subjectKeratitisen_US
dc.subjectEfficacyen_US
dc.subjectGrowthen_US
dc.titleAntibacterial activity of propolis against MRSA and synergism with topical mupirocinen_US
dc.typeArticleen_US

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