Association of serum KL-6 levels with interstitial lung disease in patients with connective tissue disease: a cross-sectional study

Basit Öğe Kaydı
dc.authoridAtes, Askin/0000-0003-1966-3333
dc.authoridkucuksahin, orhan/0000-0003-4530-2304
dc.authoridDemir, Nalan/0000-0002-3168-9176
dc.authoridTURGAY, TAHSIN MURAT/0000-0001-5302-4485
dc.contributor.authorOguz, Ekin Oktay
dc.contributor.authorKucuksahin, Orhan
dc.contributor.authorTurgay, Murat
dc.contributor.authorYildizgoren, Mustafa Turgut
dc.contributor.authorAtes, Askin
dc.contributor.authorDemir, Nalan
dc.contributor.authorKumbasar, Ozlem Ozdemir
dc.date.accessioned2024-09-18T20:11:47Z
dc.date.available2024-09-18T20:11:47Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIt was aimed to evaluate KL-6 glycoprotein levels to determine if it may be a diagnostic marker for the connective tissue diseases (CTDs) predicting CTD-related interstitial lung diseases (ILDs) (CTD-ILD) development and to examine if there was a difference between patients and healthy controls. The study included 113 patients with CTD (45 CTD without lung involvement, 68 CTD-ILD) and 45 healthy control subjects. KL-6 glycoprotein levels were analyzed with ELISA in patients and the control group. The relationship between KL-6 glycoprotein levels and CTD-ILD was assessed. In the comparison of all the groups in the study, significantly higher levels of KL-6 were determined in the CTD-ILD group than in either the CTD without pulmonary involvement group or the healthy control group (p < 0.008 and p < 0.001, respectively). There was no statistically significant difference between the KL-6 levels in the healthy control group and the CTD without pulmonary involvement group (p = 0.289). The KL-6 levels did not differ significantly according to the connective tissue diseases in the diagnostic groups (systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, mixed connective tissue disease, scleroderma, polymyositis/ dermatomyositis). In the healthy control group, there was a statistically significant difference between KL-6 levels in smokers and non-smokers. Smokers had significantly higher serum KL-6 levels compared with non-smokers (p < 0.05). There was no statistically significant difference between smoking status (pack-year) and serum KL-6 levels. There was no statistically significant correlation between serum KL-6 levels and time since diagnosis of CTD and CTD-ILD. The level of KL-6 as a predictive factor could be used to identify the clinical development of ILD before it is detected on imaging modality. Further prospective clinical studies are needed to define whether levels of KL-6 might have prognostic value or might predict progressive ILD.en_US
dc.identifier.doi10.1007/s10067-015-3167-8
dc.identifier.endpage666en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue3en_US
dc.identifier.pmid26758437en_US
dc.identifier.scopus2-s2.0-84960336376en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage663en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-015-3167-8
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9072
dc.identifier.volume35en_US
dc.identifier.wosWOS:000372429000013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConnective tissue diseaseen_US
dc.subjectConnective tissue disease-related interstitial lung diseaseen_US
dc.subjectInterstitial lung diseaseen_US
dc.subjectKrebs von den Lungen-6en_US
dc.titleAssociation of serum KL-6 levels with interstitial lung disease in patients with connective tissue disease: a cross-sectional studyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
244.63 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu