Comparison of the Protoscolocidal Effectiveness of Hypertonic Saline, Povidone-Iodine and Albendazole Solutions in an Experimental Lung Hydatid Cyst Model

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dc.contributor.authorYetim, T. Durgun
dc.contributor.authorBasoglu, A.
dc.contributor.authorSengul, A. Taslak
dc.contributor.authorYetim, I.
dc.contributor.authorBekdemir, O. Serdar
dc.contributor.authorHokelek, M.
dc.date.accessioned2024-09-18T19:52:33Z
dc.date.available2024-09-18T19:52:33Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSecondary hydatidosis is an important problem encountered during the surgical treatment of hydatid cysts. This study describes an experimental model of secondary hydatidosis by cyst inoculation, used to explore whether simultaneous inoculation of protoscolocidal agents could prevent secondary hydatidosis. Fertile cyst fluid was injected into the pleural space of rabbits alone (group 1, n = 8), and in combination with 2% albendazole solution (group 2, n = 8), 20% hypertonic saline (group 3, n = 8) or 10% povidone-iodine (group 4, n = 8). Computed tomography imaging of the thorax, indirect haemagglutination (IHA) titres and eosinophil counts were used to determine cyst development. After 16 months, three control rabbits had pneumothorax, seven had cysts and four had parenchymal nodules. Histopathological investigation of nodules revealed 87.5% cyst formation. Pleural thickening was observed in rabbits from all groups. Cyst formation rates, IHA titres and eosinophilia counts were higher in group 1 than in groups 2 - 4. This study demonstrated the experimental formation of secondary hydatidosis and found that topical protoscolocidal agents were beneficial in preventing cyst recurrence.en_US
dc.identifier.doi10.1177/147323001103900411
dc.identifier.endpage1238en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue4en_US
dc.identifier.pmid21986125en_US
dc.identifier.scopus2-s2.0-80052245494en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1230en_US
dc.identifier.urihttps://doi.org/10.1177/147323001103900411
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7508
dc.identifier.volume39en_US
dc.identifier.wosWOS:000295654500011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectALBENDAZOLEen_US
dc.subjectPOVIDONE-IODINEen_US
dc.subjectHYPERTONIC SALINEen_US
dc.subjectPROTOSOLOCIDAL AGENTSen_US
dc.subjectLUNG HYDATIDOSISen_US
dc.subjectEXPERIMENTAL MODELen_US
dc.titleComparison of the Protoscolocidal Effectiveness of Hypertonic Saline, Povidone-Iodine and Albendazole Solutions in an Experimental Lung Hydatid Cyst Modelen_US
dc.typeArticleen_US

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