The impact of propranolol on apoptosis in cutaneous squamous cell carcinomas

Basit Öğe Kaydı
dc.contributor.authorCelik, E.
dc.contributor.authorKaplan, H. M.
dc.contributor.authorSingirik, E.
dc.date.accessioned2024-09-18T20:04:24Z
dc.date.available2024-09-18T20:04:24Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVES: Cutaneous squamous cell carcinoma (cSCC) is a common cancer in Caucasian populations. Treatments registered for high-risk cSCC are still undetermined. Experimental data have demonstrated possibly useful effects of a combined application of beta-blockers in cancer therapy. The goal of this study was to examine the effi cacy of propranolol in the treatment of cSCC and its impact on apoptosis. Thus, we aimed to investigate the apoptotic pathway protein levels and activity in beta-blocker-treated cSCC cells. MATERIALS AND METHODS: The study was performed on human cSCC cancer cell line culture. One of the cSCC cell lines was treated with propranolol, whereas no treatment was given to the other group. Then, the levels of apoptotic pathway proteins were determined by ELISA test in both groups. RESULTS: The propranolol treatment group exhibited a remarkable difference as compared with the other group. It was found that propranolol treatment enhanced the activity of caspase-3 while the expression of bax, wee1, gadd153, grp78 and AIF decreased bcl-2 which is antiapoptotic protein in cSCC cell lines. CONCLUSION: Our results suggest that propranolol treatment has anti-cancer properties with an effect on various apoptotic pathways in cSCC. These data are important because propronalol may be involved in future cSCC treatment (Tab. 1, Fig. 3, Ref. 22).en_US
dc.description.sponsorshipHatay Mustafa Kemal University Scientific Projects Coordination Unit, Hatay, Turkey [17M001]en_US
dc.description.sponsorshipThis study was supported by the Hatay Mustafa Kemal University Scientific Projects Coordination Unit (Project No: 17M001), Hatay, Turkey.en_US
dc.identifier.doi10.4149/BLL_2020_131
dc.identifier.endpage804en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue11en_US
dc.identifier.pmid33164541en_US
dc.identifier.scopus2-s2.0-85095969615en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage801en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2020_131
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8139
dc.identifier.volume121en_US
dc.identifier.wosWOS:000604264500007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbeta-blockeren_US
dc.subjectpropranololen_US
dc.subjectcutaneous squamous cell carcinomaen_US
dc.subjectapoptotic pathwayen_US
dc.titleThe impact of propranolol on apoptosis in cutaneous squamous cell carcinomasen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full text
Boyut:
144.93 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu