Assessment of biochemical bone markers of osteoporosis in children with thalassemia major

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dc.authoridMotor, Sedat/0000-0003-1004-8086
dc.authoridSangun, Ozlem/0000-0002-9079-4574
dc.contributor.authorCelik, Tanju
dc.contributor.authorSangun, Ozlem
dc.contributor.authorUnal, Sule
dc.contributor.authorBalci, Ali
dc.contributor.authorMotor, Sedat
dc.date.accessioned2024-09-18T20:04:39Z
dc.date.available2024-09-18T20:04:39Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Beta thalassemia major (beta-TM) is a common cause of skeletal morbidity and is associated with increased bone fracture risk, particularly in inadequately transfused children. The aim of this study was to investigate some potential biochemical markers as possible early predictors of BMD variations in children with beta-TM. Methods The study included 38 children with beta-TM and 40 sex-age matched controls. All patients were subjected to BMD assessment by dual-energy X-ray absorptiometry (DEXA). Serum beta-crosslaps (beta-CTx), osteoprotegerin (OPG), receptor activator of nuclear factor-kappa B ligand (RANKL), urinary deoxypyridinoline (DPD) and ferritin levels were compared between the groups. Results Serum OPG levels were significantly lower in thalassemic children than in controls. The mean ratio of RANKL/OPG was significantly higher in the thalassemic patients than in the control group. Osteoporosis was detected in 10 (3 female and 7 male) of 38 patients (26.3%) according to the femur Z score and in 6 of them (4 male and 2 female) (15.8%) according to the spine Z score. Conclusions Serum OPG concentrations can be used as a biochemical marker in screening patients with beta-thalassemia major for the development of osteoporosis.en_US
dc.description.sponsorshipDepartment of Scientific Research Projects in Mustafa Kemal University [1106 M 0107]en_US
dc.description.sponsorshipThis study was funded by the Department of Scientific Research Projects (no: 1106 M 0107) in Mustafa Kemal University.en_US
dc.identifier.doi10.1186/s13052-022-01290-x
dc.identifier.issn1720-8424
dc.identifier.issn1824-7288
dc.identifier.issue1en_US
dc.identifier.pmid35725492en_US
dc.identifier.scopus2-s2.0-85132269786en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s13052-022-01290-x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8298
dc.identifier.volume48en_US
dc.identifier.wosWOS:000813760800003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofItalian Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone markersen_US
dc.subjectBone mineralization disordersen_US
dc.subjectOsteoporosisen_US
dc.titleAssessment of biochemical bone markers of osteoporosis in children with thalassemia majoren_US
dc.typeArticleen_US

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