The protective effect of darbepoetin alfa on experimental testicular torsion and detorsion injury

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dc.contributor.authorAkcora, Bulent
dc.contributor.authorAltug, Muhammed Enes
dc.contributor.authorKontas, Tunay
dc.contributor.authorAtik, Esin
dc.date.accessioned2024-09-18T20:15:01Z
dc.date.available2024-09-18T20:15:01Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Testicular torsion is a serious urological emergency, usually involving newborns, children, and adolescents which can lead to subfertility and infertility. Prevention of testicular damage caused by torsion is still a clinical and experimental problem. So far many chemicals and drugs have been investigated for decreasing ischemia/reperfusion (I/R) injury in experimental animals. The possible protective effect of darbepoetin alfa, a novel erythropoietic protein, on testicular tissue after I/R injury was examined in this study. Methods: Thirty rats were divided into three groups: sham operation, torsion/detorsion, and torsion/detorsion plus darbepoetin alfa groups. After torsion (2 hours) and detorsion (4 hours), bilateral orchiectomy was performed. Malondialdehyde, nitric oxide and glutathione levels were determined in testicular tissue. Results: Administration of darbepoetin alfa caused a decrease of malondialdehyde and nitric oxide levels and an increase in glutathione levels compared with the torsion/detorsion group. In addition, histological injury scores were significantly decreased in the treatment group more than the torsion/detorsion group. Conclusion: The results suggest that darbepoetin alfa may be a potential protective agent for preventing testicular injury caused by testis torsion.en_US
dc.identifier.doi10.1111/j.1442-2042.2007.01844.x
dc.identifier.endpage850en_US
dc.identifier.issn0919-8172
dc.identifier.issn1442-2042
dc.identifier.issue9en_US
dc.identifier.pmid17760753en_US
dc.identifier.scopus2-s2.0-34548187170en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage846en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-2042.2007.01844.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9389
dc.identifier.volume14en_US
dc.identifier.wosWOS:000249000400013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdarbepoetin alfaen_US
dc.subjecttestisen_US
dc.subjecttorsionen_US
dc.subjectdetorsionen_US
dc.titleThe protective effect of darbepoetin alfa on experimental testicular torsion and detorsion injuryen_US
dc.typeArticleen_US

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