Mean Platelet Volume, a Novel Biomarker in Adolescents with Severe Primary Dysmenorrhea

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dc.contributor.authorKucur, Suna Kabil
dc.contributor.authorSeven, Ali
dc.contributor.authorYuksel, Kadriye Beril
dc.contributor.authorSencan, Halime
dc.contributor.authorGozukara, Ilay
dc.contributor.authorKeskin, Nadi
dc.date.accessioned2024-09-18T19:50:24Z
dc.date.available2024-09-18T19:50:24Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractStudy Objective: To evaluate whether mean platelet volume (MPV) would be a profitable marker in predicting disease severity in adolescents with severe primary dysmenorrhea (PD). Design, Setting, Participants, Interventions, and Main Outcome Measures: A total of 67 patients diagnosed with PD and 37 healthy adolescents with regular menstrual cycles were included in the study. Hemoglobin, MPV, and white blood cell, platelet, lymphocyte, and neutrophil counts were measured as part of the automated complete blood examination. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio were obtained from the absolute neutrophil or platelet count, respectively, divided by the absolute lymphocyte count. The visual analog scale was used to assess the level of pain, as mild (<40 mm), moderate (40-60 mm) and severe ( >60 mm) PD. Results: The MPV level of the combined severity of PD and control groups were similar. However, the MPV was significantly lower in the severe PD group compared with the control group (P = .04). There were no significant differences in the other hematological parameters between the groups. The mean visual analog scale score of the PD and control subjects were 7.35 +/- 2.25 and 1.07 +/- 1.96, respectively (P < .01). There was a poor negative correlation, which was statistically insignificant, between MPV and white blood cell count. Conclusion: The present study showed that MPV is decreased in adolescents with severe PD. Further studies with larger numbers of subjects are necessary to clarify the roles of platelets in the pathogenesis of severe PD and evaluate the changes in MPV value in response to treatment.en_US
dc.identifier.doi10.1016/j.jpag.2016.01.128
dc.identifier.endpage392en_US
dc.identifier.issn1083-3188
dc.identifier.issn1873-4332
dc.identifier.issue4en_US
dc.identifier.pmid26876966en_US
dc.identifier.scopus2-s2.0-84964598830en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage390en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpag.2016.01.128
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7415
dc.identifier.volume29en_US
dc.identifier.wosWOS:000378986400016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Pediatric and Adolescent Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdolescenten_US
dc.subjectPrimary dysmenorrheaen_US
dc.subjectPelvic painen_US
dc.subjectMean platelet volumeen_US
dc.subjectPlateleten_US
dc.subjectVisual analog scaleen_US
dc.titleMean Platelet Volume, a Novel Biomarker in Adolescents with Severe Primary Dysmenorrheaen_US
dc.typeArticleen_US

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