The analgesic efficacy of preoperative versus postoperative lornoxicam in varicocele repair

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dc.authoridGORUR, Sadik/0000-0002-3458-5428
dc.contributor.authorInanoglu, Kerem
dc.contributor.authorGorur, Sadik
dc.contributor.authorAkkurt, Cagla Ozbakis
dc.contributor.authorGuven, Oguz E.
dc.contributor.authorKararmaz, Alper
dc.date.accessioned2024-09-18T20:29:37Z
dc.date.available2024-09-18T20:29:37Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractStudy Objective: To determine whether intravenous injection of lornoxicam 30 minutes before skin incision provides better pain relief after varicocelectomy than postoperative administration of lornoxicam. Design: Prospective, double-blind, randomized clinical investigation. Setting: Operating room and postoperative recovery area. Patients: 44 ASA physical status I and 11 adult male patients undergoing varicocelectomy. Interventions: Patients were randomized either to receive 8 mg lornoxicam infusion 30 minutes before skin incision, followed by saline infusion immediately after skin closure (group 1), or to receive the identical injections but in reverse order (group 2). All patients received local anesthesia with bupivacame. Measurements: Postoperative pain scores were evaluated hourly for the first 8 hours after surgery, then at 12, 16, 20, and 24 hours after surgery, using a 10-cm visual analog scale. Time to first analgesic request and patient's global assessments also were recorded. Main Results: Patients in group 1 reported significantly lower pain scores (P < 0.05) at all time intervals except at 24 hours and better global assessment (P = 0.001) than did group 2. There were significantly fewer patients in the preemptive group than group 2 who required rescue analgesic within the first 24 hours (0% vs 22.7%; P = 0.024). Mean time to first analgesic request was also significantly longer in the preemptive group (P = 0.001). Conclusion: Intravenous lornoxicam administered before surgery has a better analgesic effect for varicocelectomy than when administered postoperatively. (c) 2007 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jclinane.2007.06.012
dc.identifier.endpage590en_US
dc.identifier.issn0952-8180
dc.identifier.issn1873-4529
dc.identifier.issue8en_US
dc.identifier.pmid18083471en_US
dc.identifier.scopus2-s2.0-36849071523en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage587en_US
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2007.06.012
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10978
dc.identifier.volume19en_US
dc.identifier.wosWOS:000252230800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Clinical Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlornoxicamen_US
dc.subjectnonsteroidal antiinflammatory drugsen_US
dc.subjectpostoperative analgesiaen_US
dc.subjectvaricocelectomyen_US
dc.titleThe analgesic efficacy of preoperative versus postoperative lornoxicam in varicocele repairen_US
dc.typeArticleen_US

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