Acetaminophen reduces acute and persistent incisional pain after hysterectomy

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dc.authoridhakimoglu, sedat/0000-0002-1556-7996
dc.contributor.authorKoyuncu, Onur
dc.contributor.authorHakimoglu, Sedat
dc.contributor.authorUgur, Mustafa
dc.contributor.authorAkkurt, Cagla
dc.contributor.authorTurhanoglu, Selim
dc.contributor.authorSessler, Daniel
dc.contributor.authorTuran, Alparslan
dc.date.accessioned2024-09-18T19:54:20Z
dc.date.available2024-09-18T19:54:20Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: Acetaminophen is effective for acute surgical pain, but whether it reduces persistent incision pain remains unknown. We tested the primary hypothesis that patients given perioperative acetaminophen have less incisional pain three months after surgery. Our secondary hypotheses were that patients randomized to acetaminophen have less postoperative pain and analgesic consumption, and better functional recovery at three months. METHODS: 140 patients having abdominal hysterectomy were randomly assigned to: 1)intravenous acetaminophen (4 g/day for 72 postoperative hours); or, 2) saline placebo. The primary outcome was incisional pain visual analog scale (VAS) at three months after surgery. The secondary outcomes were (1, 2) postoperative VAS scores while laying and sitting and (3) total patient-controlled intravenous tramadol consumption during the initial 24 hours, (4) DN4 questionnaires and (5) SF-12 at three months after surgery. RESULTS: The persistent incisional pain scores at three months were significantly lower in acetaminophen (median [121, Q3]: 0 [0, 01) as compared with saline group (0 [0, 1]) (P = 0.002). Specifically, 89%, 9%, and 2% of acetaminophen patients with VAS pain score at three months of 0, 1, and 2 or more, as compared with 66%, 23%, and 10% in the saline group (odds ratio: 2.19 (95% CI: 1.33, 3.59), P = 0.002). Secondly, postoperative pain scores both laying and sitting were significantly lower in the acetaminophen group. Acetaminophen group had significantly better DN4 score and mental health related but not physical health related quality of life. CONCLUSIONS: Our results suggest that acetaminophen reduces the risk and intensity of persistent incisional pain. However, there are other mechanisms by which acetaminophen might reduce persistent pain.en_US
dc.description.sponsorshipTUBITAK: Technology and Innovation Support Programs, Directorate of the Scientific and Research Council of Turkeyen_US
dc.description.sponsorshipThe study was supported by a grant for life expenses from TUBITAK: Technology and Innovation Support Programs, Directorate of the Scientific and Research Council of Turkey.en_US
dc.identifier.endpage366en_US
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.issue4en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7671
dc.identifier.volume89en_US
dc.identifier.wosWOS:000445319300014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherEdizioni Luigi Pozzien_US
dc.relation.ispartofAnnali Italiani Di Chirurgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnesthesiaen_US
dc.subjectacetaminophenen_US
dc.subjectPersistent surgical painen_US
dc.subjectPostoperative acute painen_US
dc.titleAcetaminophen reduces acute and persistent incisional pain after hysterectomyen_US
dc.typeArticleen_US

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