Biomarkers in premature calves with and without respiratory distress syndrome

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dc.authoridERTURK, ALPER/0000-0002-4271-7953
dc.authoridPARLAK, Tugba Melike/0000-0003-3277-0336
dc.authoridNASERI, AMIR/0000-0001-9140-5879
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridDURGUT, MURAT KAAN/0000-0002-4582-8536
dc.contributor.authorIder, Merve
dc.contributor.authorNaseri, Amir
dc.contributor.authorOk, Mahmut
dc.contributor.authorUney, Kamil
dc.contributor.authorErturk, Alper
dc.contributor.authorDurgut, Murat K.
dc.contributor.authorParlak, Tugba M.
dc.date.accessioned2024-09-18T20:16:53Z
dc.date.available2024-09-18T20:16:53Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Approaches to the evaluation of pulmonary arterial hypertension (PAH) in premature calves by using lung-specific epithelial and endothelial biomarkers are needed. Objective To investigate the evaluation of PAH in premature calves with and without respiratory distress syndrome (RDS) by using lung-specific epithelial and endothelial biomarkers and determine the prognostic value of these markers in premature calves. Animals Fifty premature calves with RDS, 20 non-RDS premature calves, and 10 healthy term calves. Methods Hypoxia, hypercapnia, and tachypnea were considered criteria for RDS. Arterial blood gases (PaO2, PaCO2, oxygen saturation [SO2], base excess [BE], and serum lactate concentration) were measured to assess hypoxia. Serum concentrations of lung-specific growth differentiation factor-15 (GDF-15), asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and surfactant protein D (SP-D) were measured to assess PAH. Results Arterial blood pH, PaO2, SO2, and BE of premature calves with RDS were significantly lower and PaCO2 and lactate concentrations higher compared to non-RDS premature and healthy calves. The ADMA and SP-D concentrations of premature calves with RDS were lower and serum ET-1 concentrations higher than those of non-RDS premature and healthy calves. No statistical differences for GDF-15 and VEGF were found among groups. Conclusions and Clinical Importance Significant increases in serum ET-1 concentrations and decreases in ADMA and SP-D concentrations highlight the utility of these markers in the diagnosis of PAH in premature calves with RDS. Also, we found that ET-1 was a reliable diagnostic and prognostic biomarker for PAH and predicting mortality in premature calves.en_US
dc.description.sponsorshipSelcuk University Scientific Research Project Office [20401007]en_US
dc.description.sponsorshipSelcuk University Scientific Research Project Office, Grant/Award Number: 20401007en_US
dc.identifier.doi10.1111/jvim.16217
dc.identifier.endpage2533en_US
dc.identifier.issn0891-6640
dc.identifier.issn1939-1676
dc.identifier.issue5en_US
dc.identifier.pmid34227155en_US
dc.identifier.scopus2-s2.0-85109063696en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2524en_US
dc.identifier.urihttps://doi.org/10.1111/jvim.16217
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9793
dc.identifier.volume35en_US
dc.identifier.wosWOS:000669671700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Internal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectendothelial biomarkersen_US
dc.subjectpremature calfen_US
dc.subjectpulmonary epitheliumen_US
dc.subjectpulmonary hypertensionen_US
dc.subjectRDSen_US
dc.titleBiomarkers in premature calves with and without respiratory distress syndromeen_US
dc.typeArticleen_US

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