The efficacy of vitamin E in the prevention of lung ischemia-reperfusion injury after cardiopulmonary bypass in open heart surgery

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dc.authorscopusid6506832953
dc.authorscopusid6603633979
dc.authorscopusid7003875728
dc.authorscopusid55304430700
dc.authorscopusid6602412924
dc.authorscopusid20733795800
dc.authorscopusid7005322966
dc.contributor.authorAcipayam, Mehmet
dc.contributor.authorSunar, Hasan
dc.contributor.authorCanbaz, Suat
dc.contributor.authorHüseyinova, Gülara
dc.contributor.authorErbaş, Hakan
dc.contributor.authorErten, Oya
dc.contributor.authorDuran, Enver
dc.date.accessioned2024-09-19T15:45:25Z
dc.date.available2024-09-19T15:45:25Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The purpose of the study was to investigate the effects of vitamin E in the protection of the lung from potential ischemia-reperfusion injury during elective coronary artery bypass graft surgery. Material and Methods: This controlled randomized single-center study included patients who underwent elective coronary bypass grafting (CABG) operation. Forty-nine patients were randomly divided into 2 groups. Water soluble Vitamin E (100 mg) in tepid saline (n=25) or tepid saline alone (n=24) was administered via the jugular vein before the aortic cross clamping. Serum total antioxidant capacity (TAC) levels and serum malonedialdehyde levels (MDA) were measured. Pulmonary biopsies were obtained before the aortic cross clamping and 60 minutes after removing the cross clamp. Biopsies were examined histopathologically under electron microscopy. Results: Serum MDA levels at T1 (15 minutes after removal of the cross clamp) and T2 (30 minutes after removal of the cross clamp) were higher in the control group compared to the Vitamin group. Serum TAC levels at T1, T2 and T3 (60 minutes after removal of the cross clamp) were higher in the Vitamin E group compared to the control group. Histopathologic injury grade was lower in the Vitamin E group than in the control group. Conclusion: Vitamin E was found to be protective against reperfusion induced oxidative injury in the early operative period. © 2013 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2012-31228
dc.identifier.endpage784en_US
dc.identifier.issn1300-0292
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84879165624en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage777en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2012-31228
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14674
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiopulmonary bypassen_US
dc.subjectLung injuryen_US
dc.subjectReperfusion injuryen_US
dc.subjectVitamin Een_US
dc.titleThe efficacy of vitamin E in the prevention of lung ischemia-reperfusion injury after cardiopulmonary bypass in open heart surgeryen_US
dc.title.alternativeAçık kalp cerrahisi sırasında kardiyopulmoner baypas sonrası oluşan akci?er İskemisi-reperfüzyon hasarını önlemede E Vitamininin etkinli?ien_US
dc.typeArticleen_US

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