Assessment of left ventricular dyssynchrony in patients with psoriasis

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dc.contributor.authorSen, Bilge Bulbul
dc.contributor.authorRifaioglu, Emine Nur
dc.contributor.authorEkiz, Ozlem
dc.contributor.authorBuyukkaya, Eyup
dc.contributor.authorKurt, Mustafa
dc.contributor.authorKarakas, Mehmet Fatih
dc.contributor.authorBuyukkaya, Sule
dc.date.accessioned2024-09-18T21:05:14Z
dc.date.available2024-09-18T21:05:14Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Psoriasis is an inflammatory disorder, which has been reported to be associated with cardiovascular (CV) risks. Although increased CV risks in psoriasis are well established, there are no data about changes of contraction synchrony in psoriasis. Therefore, we aimed to study the left ventricular (LV) contraction synchrony in patients with psoriasis with narrow QRS and normal ejection fraction. Methods Fifty patients with psoriasis and 50 age- and sex-matched control subjects were included in the study. LV dyssynchrony was investigated by color-coded tissue Doppler imaging. Results In the psoriasis group, the mean high-sensitive C-reactive protein values were significantly higher compared with the controls. Peak A velocity, deceleration time, isovolumetric relaxation time, and E/E' values were higher in the psoriasis group; however, E/A ratio and average Em were higher in the control group. LV systolic dyssynchrony parameters [including standard deviation of Ts of the 12 LV segments (Ts-SD-12), maximal difference in Ts between any two of the 12 LV segments, standard deviation of Ts of the six basal LV segments, and maximal difference in Ts between any two of the six basal LV segments] were found to be higher in the psoriasis group. The patients with ventricular dyssynchrony (a Ts-SD-12 > 34.4 ms) were higher in the psoriasis group than the control group (34% vs. 6%, P < 0.01). Conclusion In patients with psoriasis with normal ejection fractions and narrow QRS, LV systolic dyssynchrony is an early manifestation of heart involvement and may coexist with diastolic dysfunction.en_US
dc.identifier.doi10.1111/ijd.12192
dc.identifier.endpage1227en_US
dc.identifier.issn0011-9059
dc.identifier.issn1365-4632
dc.identifier.issue10en_US
dc.identifier.pmid25219512en_US
dc.identifier.scopus2-s2.0-84907807249en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1221en_US
dc.identifier.urihttps://doi.org/10.1111/ijd.12192
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13467
dc.identifier.volume53en_US
dc.identifier.wosWOS:000342816600023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofInternational Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiastolic Heart-Failureen_US
dc.subjectCardiac Resynchronization Therapyen_US
dc.subjectImpaired Endothelial Functionen_US
dc.subjectSystolic Asynchronyen_US
dc.subjectMyocardial-Infarctionen_US
dc.subjectDiabetes-Mellitusen_US
dc.subjectRisk-Factorsen_US
dc.subjectDiseaseen_US
dc.subjectAtherosclerosisen_US
dc.subjectAbnormalitiesen_US
dc.titleAssessment of left ventricular dyssynchrony in patients with psoriasisen_US
dc.typeArticleen_US

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