Lipoprotein Subfraction Profile and HDL-Associated Enzymes in Sickle Cell Disease Patients

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dc.authoridYonden, Zafer/0000-0003-0708-5417
dc.authoridAslan, Mutay/0000-0002-0660-971X
dc.contributor.authorOzturk, Oktay H.
dc.contributor.authorCan, Yesim
dc.contributor.authorYonden, Zafer
dc.contributor.authorMotor, Sedat
dc.contributor.authorOktay, Gonul
dc.contributor.authorKaya, Hasan
dc.contributor.authorAslan, Mutay
dc.date.accessioned2024-09-18T20:57:01Z
dc.date.available2024-09-18T20:57:01Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAlthough hypocholesterolemia is a reported finding in sickle cell disease (SCD), low-density lipoprotein (LDL)/high-density lipoprotein (HDL) subfractions and HDL-associated enzymes have not been determined in SCD patients. Blood was collected from 38 hemoglobin (Hb)A volunteers and 45 homozygous HbSS patients who had not received blood transfusions in the last 3 months. Serum lipids were measured by automated analyzer while LDL and HDL subfraction analysis was done by continuous disc polyacrylamide gel electrophoresis. Serum levels of cholesteryl ester transfer protein (CETP), lecithin-cholesterol acyltransferase (LCAT), apolipoprotein B (apoB) and apolipoprotein A-1 (apoA-I) were determined by enzyme-linked immunosorbent assay (ELISA). Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels were significantly decreased, while TG levels were significantly increased in SCD patients compared to controls. A significant decrease in intermediate-density lipoprotein (IDL)-C, IDL-B, IDL-A and LDL-1 fractions were seen in SCD patients, while no significant difference was observed in small dense LDL particles. A significant decrease was seen in HDL-large, HDL-intermediate and HDL-small fractions in SCD patients versus controls. Levels of LCAT and ApoA-1 protein measured in SCD patients were significantly lower while no significant difference was observed in CETP and ApoB protein levels compared to controls. The reduction observed in LDL- and HDL-C in SCD patients was reflected as significantly decreased IDL, LDL-1 and HDL-subfractions. Decreased HDL subfractions may possibly lead to the reduced ApoA-1 and LCAT protein levels observed in SCD patients.en_US
dc.description.sponsorshipMustafa Kemal University Research Foundation [1204 U 0104]en_US
dc.description.sponsorshipThis work was supported by a grant (No. 1204 U 0104) from the Mustafa Kemal University Research Foundation.en_US
dc.identifier.doi10.1007/s11745-013-3849-4
dc.identifier.endpage1226en_US
dc.identifier.issn0024-4201
dc.identifier.issn1558-9307
dc.identifier.issue12en_US
dc.identifier.pmid24113910en_US
dc.identifier.scopus2-s2.0-84890070636en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1217en_US
dc.identifier.urihttps://doi.org/10.1007/s11745-013-3849-4
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12240
dc.identifier.volume48en_US
dc.identifier.wosWOS:000327408300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofLipidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSickle cell diseaseen_US
dc.subjectLow-density lipoproteinen_US
dc.subjectHigh-density lipoproteinen_US
dc.subjectCholesteryl ester transfer proteinen_US
dc.subjectLecithin-cholesterol acyltransferaseen_US
dc.subjectApolipoprotein A-1en_US
dc.subjectapolipoprotein Ben_US
dc.titleLipoprotein Subfraction Profile and HDL-Associated Enzymes in Sickle Cell Disease Patientsen_US
dc.typeArticleen_US

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