Investigation of the effect of cornelian cherry (Cornus mas L.) fruit extract against cisplatin-induced renal cell injury in vitro

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dc.authorid/0000-0002-0636-4214
dc.authoridALBAYRAK, Harun/0000-0002-4468-2790
dc.authoridSozmen, Mahmut/0000-0001-7976-4051
dc.contributor.authorYarim, Gul Fatma
dc.contributor.authorKazak, Filiz
dc.contributor.authorSozmen, Mahmut
dc.contributor.authorKoca, Ilkay
dc.contributor.authorAlbayrak, Harun
dc.contributor.authorYarim, Murat
dc.contributor.authorCenesiz, Sena
dc.date.accessioned2024-09-18T20:11:27Z
dc.date.available2024-09-18T20:11:27Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the protective effects of cornelian cherry fruit extract against cisplatin- induced nephrotoxicity in vitro. Materials and methods: African green monkey kidney epithelial cells (Vero) were incubated with 100 mg/mL of cornelian cherry fruit extract, 50 mu mol/L of cisplatin or 50 mu mol/L of cisplatin plus 100 mg/mL of cornelian cherry fruit extract for 4 h. The wells containing cells without any supplementation served as control. Cell viability was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazoliumbromide assay. Culture mediums were collected, centrifuged and analyzed for malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPx). Results: The cell viability was 59% in cells co-treated with cisplatin and cornelian cherry fruit extract simultaneously and 42% in cisplatin treated cells. The cellular damage ratio was elevated in cells treated with cisplatin. However, when cisplatin combined with cornelian cherry fruit extract the deleterious effects of cisplatin were significantly decreased. The MDA concentration was significantly higher (p < 0.05), GSH concentration and GPx and SOD activities were significantly lower (p < 0.05) in cisplatin treated group when compared with control group, cornelian cherry group, and cisplatin + cornelian cherry group. Conclusion: The present study indicated that cornelian cherry fruit extract exert protective effects on oxidative damage in vitro induced by cisplatin.en_US
dc.identifier.doi10.1515/tjb-2016-0136
dc.identifier.endpage443en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85028772489en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2016-0136
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8861
dc.identifier.volume42en_US
dc.identifier.wosWOS:000409300500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectCornelian cherryen_US
dc.subjectOxidative damageen_US
dc.subjectIn vitroen_US
dc.subjectNephrotoxicityen_US
dc.titleInvestigation of the effect of cornelian cherry (Cornus mas L.) fruit extract against cisplatin-induced renal cell injury in vitroen_US
dc.typeArticleen_US

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