Ameliorative effect of lycopene on antioxidant status in Cyprinus carpio during pyrethroid deltamethrin exposure

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dc.authoridYonar, M. Enis/0000-0001-9519-4247
dc.contributor.authorYonar, M. Enis
dc.contributor.authorSakin, Fatih
dc.date.accessioned2024-09-18T20:54:12Z
dc.date.available2024-09-18T20:54:12Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the ameliorative properties of lycopene against the toxic effects of deltamethrin (DM) by examining oxidative damage markers such as lipid peroxidation and the antioxidant defense system components in carp (Cyprinus carpio). The fish were divided into seven groups of 15 fish each and received the following treatments: Group 1, no treatment; Group 2, orally administered corn oil; Group 3, oral lycopene (10 mg/kg body weight); Group 4, exposure to 0.018 mu g/L DM; Group 5, exposure to 0.018 mu 4/L DM plus oral administration of 10 mg/kg lycopene; Group 6, exposure to 0.036 mu g/L DM; and Group 7, exposure to 0.036 mu g/L. DM plus oral administration of 10 mg/kg lycopene. Treatment was continued for 14 days, and at the end of this period, blood and tissue (liver, kidney, and gill) samples were collected. Levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were determined in blood and tissues for measurement of oxidant-antioxidant status. A significant elevation in the level of MDA, as an index of lipid peroxidation, and reductions in antioxidant enzyme activities (SOD, CAT, and GSH-Px) and low molecular weight antioxidant (GSH) levels were observed in DM-exposed fish. Treatment with lycopene attenuated the DM-induced oxidative stress by significantly decreasing the levels of MDA. In addition, lycopene significantly increased the SOD, CAT, and GSH-Px activities and the level of GSH. The present results suggest that administration of lycopene might alleviate DM-induced oxidative stress. (C) 2011 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pestbp.2010.12.008
dc.identifier.endpage231en_US
dc.identifier.issn0048-3575
dc.identifier.issn1095-9939
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-79952006734en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage226en_US
dc.identifier.urihttps://doi.org/10.1016/j.pestbp.2010.12.008
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11664
dc.identifier.volume99en_US
dc.identifier.wosWOS:000288419800004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofPesticide Biochemistry and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPesticidesen_US
dc.subjectDeltamethrinen_US
dc.subjectLycopeneen_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidant enzymesen_US
dc.subjectFishen_US
dc.titleAmeliorative effect of lycopene on antioxidant status in Cyprinus carpio during pyrethroid deltamethrin exposureen_US
dc.typeArticleen_US

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