Protective Effect of Colchicine on Ovarian Ischemia-Reperfusion Injury: An Experimental Study

Basit Öğe Kaydı
dc.authoridDelibasi, Tuncay/0000-0002-5780-8209
dc.authoridDogan, Murat/0000-0003-0002-8428
dc.contributor.authorKurt, Raziye Keskin
dc.contributor.authorDogan, Ayse Citil
dc.contributor.authorDogan, Murat
dc.contributor.authorAlbayrak, Aynur
dc.contributor.authorKurt, Sefika Nur
dc.contributor.authorEren, Furkan
dc.contributor.authorOkyay, Ayse Guler
dc.date.accessioned2024-09-18T20:53:01Z
dc.date.available2024-09-18T20:53:01Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The aim of the present study is to investigate the efficiency of colchicine in the experimental rat ovarian torsion model in the light of histological and biochemical data. Study Design: A total of 35 Wistar albino female rats were randomly divided into 5 groups, group 1: (control-sham operated, n = 7); group 2: (torsion/detorsion, n = 7) 2 hours of ischemia and 2 hours of reperfusion; group 3: (torsion/detorsion, n = 7), 2 hours of ischemia and 5 days of reperfusion; group 4: (torsion/detorsion, n = 7) 2 hours of ischemia and 2 hours of reperfusion and a signal dose of oral 1 mL/kg colchicine; and group 5: (torsion/detorsion, n = 7), 2 hours of ischemia and 5 days of reperfusion and 5 days of oral 1 mg/kg colchicine. Histopathologic evaluation was performed by a scoring that assesses congestion, bleeding, edema, and cellular degeneration in the ovarian tissue. Catalase, tissue malondialdehyde (MDA), and protein carbonyl levels were calculated. Results: The histopathologic scores, MDA, and protein carbonyl levels in the control and colchicine groups were significantly lower than groups 2 and 3 (P < .001). Catalase activities were significantly higher in the control and colchicine groups than in groups 2 and 3 (P < .001). The results of the histopathologic parameters and biochemical markers showed that protective effects of colchicine treatment persisted up to 5 days. Conclusion: Our study results revealed that colchicine reduced ovarian ischemia-reperfusion injury in experimental rat ovarian torsion model. As the ovarian detorsion is the first choice of the treatment modality in the early phase, antioxidant and anti-inflammatory treatment modalities like colchicine might be used to reduce ovarian ischemia-reperfusion injury.en_US
dc.description.sponsorshipTurkish Academy of Science (TUBA)en_US
dc.description.sponsorshipErsin Fadillioglu and Tuncay Delibasi were partly supported by The Turkish Academy of Science (TUBA).en_US
dc.identifier.doi10.1177/1933719114553065
dc.identifier.endpage550en_US
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.issue5en_US
dc.identifier.pmid25305128en_US
dc.identifier.scopus2-s2.0-84930694230en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.1177/1933719114553065
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11541
dc.identifier.volume22en_US
dc.identifier.wosWOS:000353996500005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectovarian torsionen_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjectcolchicineen_US
dc.titleProtective Effect of Colchicine on Ovarian Ischemia-Reperfusion Injury: An Experimental Studyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
389.97 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu