Electron microscopic examination of effects of bogma raki and walnut on cochlea: An experimental study

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dc.authoridSargon, Mustafa Fevzi/0000-0001-6360-6008
dc.contributor.authorCevik, C.
dc.contributor.authorOzler, G. S.
dc.contributor.authorArli, C.
dc.contributor.authorTatar, I.
dc.contributor.authorSargon, M. F.
dc.contributor.authorZeren, C.
dc.contributor.authorYonden, Z.
dc.date.accessioned2024-09-18T20:11:33Z
dc.date.available2024-09-18T20:11:33Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIllegal alcohol beverages known as bognna raki in our country are consumed widely in our region. The studies investigating the relationship between alcohol consumption and hearing ability report different results. In this study, we aimed to investigate the toxic effects of bogma raki that contains neurotoxic substances on cochlea by electron microscopy. To the best of our knowledge, this study is the first in the literature. A total of 48 Wistar male albino rats (aged 12-16 weeks and weighing 200-240 g) were used in the study. The rats were divided into 4 groups with 12 animals in each group. The groups include control, bogma raki, walnut, and walnut + bogma raki groups. Bogma raki (30% v/v, 9.2 ml kg(-1) day(-1)) is added to drinking water of rats in bogma raki group (n = 12) for 4 weeks. Walnut group rats (n = 12) are fed with standard rat food and walnut without limitation (10 g kg(-1) day(-1)). Bogma raki + walnut group rats (n = 12) are fed with standard rat food and walnut and bogma raki is added to drinking water. The cochleas were dissected and removed en bloc and examined by electron microscopy. Perineuronal oedema around neurons of spiral ganglion and hairy cells of organ of Corti were present in the bogma raki group, walnut group and bogma raki + walnut group under electron microscopic examination. Comparing these three groups, there were no differences in the ultrastructural pathological changes. In the ultrastructural examination of the myelinated axons forming cochlear nerve, no ultrastructural pathology was detected in all the groups.en_US
dc.identifier.doi10.1177/0960327114537323
dc.identifier.endpage271en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue3en_US
dc.identifier.pmid24925365en_US
dc.identifier.scopus2-s2.0-84923384620en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage266en_US
dc.identifier.urihttps://doi.org/10.1177/0960327114537323
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8937
dc.identifier.volume34en_US
dc.identifier.wosWOS:000349504200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCochleaen_US
dc.subjectbogma rakien_US
dc.subjectwalnuten_US
dc.subjectelectron microscopeen_US
dc.titleElectron microscopic examination of effects of bogma raki and walnut on cochlea: An experimental studyen_US
dc.typeArticleen_US

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