Effect of propolis on healing in experimental colon anastomosis in rats

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dc.authoridUZUN GOCMEN, Semire/0000-0003-0783-6014
dc.authoridTEMIZ, ABDULKERIM/0000-0001-8789-6003
dc.authoridGonenci, Ramazan/0000-0002-4043-2612
dc.contributor.authorTemiz, Muhyittin
dc.contributor.authorAslan, Ahmet
dc.contributor.authorCanbolant, Elif
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorPolat, Gurbuz
dc.contributor.authorUzun, Semire
dc.contributor.authorTemiz, Abdulkerim
dc.date.accessioned2024-09-18T19:54:18Z
dc.date.available2024-09-18T19:54:18Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Propolis is the generic name for the resinous substance collected by honeybees, which is known to have antioxidant, anti-inflammatory, apoptosis-inducible effects. Anastomotic dehiscence after colorectal surgery is an important cause of morbidity and mortality. We aimed to assess the effect of propolis on healing in an experimental colon anastomosis in rats. Methods: Forty adult male Wistar albino rats were randomly assigned into 5 treatment groups with 8 rats in each: Group I, anastomosis+no treatment; Group II, anastomosis+oral propolis ( 600 mg/ kg/ d); Group III, anastomosis+oral ethyl alcohol ( 1 cc/ d); Group IV, anastomosis+rectal propolis ( 600 mg/ kg/ d); Group V, anastomosis+rectal ethyl alcohol ( 1 cc/ d). The bursting pressures, hydroxiproline levels and histopathological changes in each group were measured. Results: When bursting pressures were compared between groups, we observed that they were increased in the groups treated with propolis in contrast to all other groups. Hydroxiproline levels in the propolis groups were also significantly increased in contrast to the other groups. There was also a statistically significant difference in histopathological changes between the treatment types. When propolis administration methods were compared, we did not observe a statistically significant difference. Conclusion: Propolis has a significantly favourable effect on healing in experimental colon anastomosis, independent from the method of administration.en_US
dc.identifier.doi10.1007/s12325-008-0013-2
dc.identifier.endpage167en_US
dc.identifier.issn0741-238X
dc.identifier.issue2en_US
dc.identifier.pmid18309466en_US
dc.identifier.scopus2-s2.0-58749113085en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage159en_US
dc.identifier.urihttps://doi.org/10.1007/s12325-008-0013-2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7645
dc.identifier.volume25en_US
dc.identifier.wosWOS:000255873300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAdvances in Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanastomosisen_US
dc.subjectcolonen_US
dc.subjecthealingen_US
dc.subjectpropolisen_US
dc.titleEffect of propolis on healing in experimental colon anastomosis in ratsen_US
dc.typeArticleen_US

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