Large joint and lower extremity involvement have higher impact on disease outcomes in oligoarticular psoriatic arthritis

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dc.authoridDuruoz, Mehmet Tuncay/0000-0003-3584-2788
dc.authoridOzisler, Cem/0000-0001-7475-3927
dc.authoridSolmaz, Dilek/0000-0002-9035-689X
dc.authoridkucuksahin, orhan/0000-0003-4530-2304
dc.authoridAyan, Gizem/0000-0003-1889-9619
dc.authoridaksu, kenan/0000-0001-8889-2688
dc.contributor.authorAyan, Gizem
dc.contributor.authorSolmaz, Dilek
dc.contributor.authorBakirci, Sibel
dc.contributor.authorTinazzi, Ilaria
dc.contributor.authorOmma, Ahmet
dc.contributor.authorKucuksahin, Orhan
dc.contributor.authorOzisler, Cem
dc.date.accessioned2024-09-18T20:52:52Z
dc.date.available2024-09-18T20:52:52Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective Joints with different sizes and anatomical locations can be affected in psoriatic arthritis (PsA). Our aim was to explore the effect of different joint patterns on patient-reported outcomes (PROs) in patients with mono-oligoarthritis. Methods Within PsArt-ID (Psoriatic Arthritis- International Database), 387/1670 patients who had mono-oligoarthritis (1-4 tender and swollen joints) were enrolled in cross-sectional assessment. The joints were categorized according to their size (small/large) and location (upper/lower extremity) and PROs, physician global assessment and C-reactive protein (CRP) were compared. Analysis was made by categorizing according to joint counts (1-2 joints/ 3-4 joints). Results The mean age (SD) was 46.9 (14.24) with a mean (SD) PsA duration of 3.93 (6.03) years. Within patients with 1-2 involved joints (n = 302), size of the joints only had an impact on CRP values with large joints having higher CRP (P = .005), similar to lower extremity involvement (P = .004). PROs were similar regardless of size or location if 1-2 joints were inflamed. Within patients with 3-4 involved joints (n = 85), patient global assessment (PGA), pain, fatigue and physician global assessment were higher in the group with large joints. Similarly, PGA, pain, and physician global assessment were higher in patients with lower extremity involvement as well as higher CRP values. Conclusion For PsA patients with 3-4 joints involved, lower extremity and large joints are associated with poorer outcomes with worse PROs, physician global assessment, and higher CRP. The size and anatomical location of the joints are less important for patients with 1-2 joints in terms of the PROs.en_US
dc.description.sponsorshipUnion Chimique Belge (UCB); Scientific and Technological Research Council of Turkey (TUBITAK)en_US
dc.description.sponsorshipThis work was supported by the Union Chimique Belge (UCB) (to Dilek Solmaz for axial spondyloarthritis fellowship) and the Scientific and Technological Research Council of Turkey (TUBITAK) (to Sibel Bakirci).en_US
dc.identifier.doi10.1111/1756-185X.13887
dc.identifier.endpage1099en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue8en_US
dc.identifier.pmid32567814en_US
dc.identifier.scopus2-s2.0-85087316315en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1094en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.13887
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11453
dc.identifier.volume23en_US
dc.identifier.wosWOS:000541509700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectoligoarthritisen_US
dc.subjectpatient-reported outcomesen_US
dc.subjectpsoriatic arthritisen_US
dc.titleLarge joint and lower extremity involvement have higher impact on disease outcomes in oligoarticular psoriatic arthritisen_US
dc.typeArticleen_US

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