Determination of Ethanol in Blood Samples Using Partial Least Square Regression Applied to Surface Enhanced Raman Spectroscopy

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dc.authoridAcikgoz, Gunes/0000-0001-9118-3153
dc.contributor.authorAcikgoz, Gunes
dc.contributor.authorHamamci, Berna
dc.contributor.authorYildiz, Abdulkadir
dc.date.accessioned2024-09-18T20:04:36Z
dc.date.available2024-09-18T20:04:36Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAlcohol consumption triggers toxic effect to organs and tissues in the human body. The risks are essentially thought to be related to ethanol content in alcoholic beverages. The identification of ethanol in blood samples requires rapid, minimal sample handling, and non-destructive analysis, such as Raman Spectroscopy. This study aims to apply Raman Spectroscopy for identification of ethanol in blood samples. Silver nanoparticles were synthesized to obtain Surface Enhanced Raman Spectroscopy (SERS) spectra of blood samples. The SERS spectra were used for Partial Least Square (PLS) for determining ethanol quantitatively. To apply PLS method, 920-820 cm(-1) band interval was chosen and the spectral changes of the observed concentrations statistically associated with each other. The blood samples were examined according to this model and the quantity of ethanol was determined as that: first a calibration method was established. A strong relationship was observed between known concentration values and the values obtained by PLS method (R-2 = 1). Second instead of then, quantities of ethanol in 40 blood samples were predicted according to the calibration method. Quantitative analysis of the ethanol in the blood was done by analyzing the data obtained by Raman spectroscopy and the PLS method.en_US
dc.identifier.doi10.5487/TR.2018.34.2.127
dc.identifier.endpage132en_US
dc.identifier.issn1976-8257
dc.identifier.issn2234-2753
dc.identifier.issue2en_US
dc.identifier.pmid29686774en_US
dc.identifier.scopus2-s2.0-85046808989en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.5487/TR.2018.34.2.127
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8269
dc.identifier.volume34en_US
dc.identifier.wosWOS:000431100500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofToxicological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlood samplesen_US
dc.subjectRaman spectroscopyen_US
dc.subjectSurface Enhanced Raman Spectroscopyen_US
dc.subjectSilver nanoparticlesen_US
dc.titleDetermination of Ethanol in Blood Samples Using Partial Least Square Regression Applied to Surface Enhanced Raman Spectroscopyen_US
dc.typeArticleen_US

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