An Investigation of Correlation Between Electrophysiological and Functional Recovery After the Sciatic Nerve Injury

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dc.contributor.authorGuven, Mustafa
dc.contributor.authorKahraman, Ibrahim
dc.contributor.authorGunay, Ismail
dc.date.accessioned2024-09-18T20:25:10Z
dc.date.available2024-09-18T20:25:10Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractPurpose: Video or photo assisted footprint analysis method is used to determine the motor and sensorial development instead of classic walking track footprint analysis in experimental peripheral nerve injury. Besides, the sucrose-gap method is used for measuring the electrophysiological activity in the sciatic nerves in-vitro. The aim of this study is to investigate the relationship between functional and electrophysiological recovery during the nerve regeneration in Wistar rats. Methods: In the experiments, after the unilateral sciatic nerve crushing, the rats were evaluated at the preoperative and 2nd, 4th, 6th and 8th weeks postoperative using the sucrose gap method, and photo assisted footprint method. The compound action potentials (CAP), the Peak-time (PT) and the 1/2 Falling-time (1/2FT) were measured, and compared to functional results. Results: Two weeks after being crushed sciatic nerves, complete function loss was seen operated legs in all rats. The amplitude of CAP was determined too small. The PT and the 1/2FT values were three fold longer than intact. However, following 4th - 8th weeks, the amplitude of CAP and other parameters of CAP were closed to intact values. Conclusion: The findings indicated that the results of the functional recovery were correlated to electrophysiological results. However, functional results showed almost full functional recovery in the 4th week, the electrophysiological results did not reach to intact values in the 8th week. We conclude that photo assisted footprint analysis method and sucrose-gap technique, which are useful functional and electrophysiological methods to produce complementary knowledge with each other in the investigation of experimental peripheral nerve regeneration.en_US
dc.description.sponsorshipTUBITAK-SBG [106S220]en_US
dc.description.sponsorshipThis study was supported partially by grants from the TUBITAK-SBG (106S220).en_US
dc.identifier.endpage185en_US
dc.identifier.issn0250-5150
dc.identifier.issue4en_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10132
dc.identifier.volume37en_US
dc.identifier.wosWOS:000216436800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFootprinten_US
dc.subjectcompound action potentialen_US
dc.subjectsucrose-gapen_US
dc.subjectcrushen_US
dc.subjectregenerationen_US
dc.subjectsciatic nerveen_US
dc.titleAn Investigation of Correlation Between Electrophysiological and Functional Recovery After the Sciatic Nerve Injuryen_US
dc.typeArticleen_US

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