Analysis of The Histopathological Changes of Epidural Space and Endoneural Structure in Lumbar Spinal Canal Stenosis: a Model For Chronic Compression of The Rat Cauda Equina

[ N/A ]

Tarih

2011

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Journal Neurological Sciences

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Objective: The purpose of study was to produce chronic cauda equina compression in rats for analysis of the histopathologic changes of two different group. Method: Twenty-one adult male Wistar rats were studied. A single-lumen polyurethane catheter was used. Seven rats, the sham-operated group, had laminectomy only. The spinal canal was obstructed 25% in seven rats, 65% in another seven. Obstruction area of the group that was obstructed 25% and 65%, proximal and distal region of this area and laminectomy area of the sham-operated group of which only laminectomy was applied were examined even in epidural space and endoneural structures histopathologically. In consideration of information that were obtained from examinations; hemorrhage, inflammation, fibroblast proliferation, capillary proliferation in epidural space; nerve fiber damage, edema, inflammation and hemorrhage parameters in endoneural structures were evaluated by mild, moderate and severe categories. Results: No nerve fiber damage was present in laminectomy area and its proximal and distal of the sham-operated group. All samples from the obstruction area in the 25% and 65% obstructed groups showed nerve fiber damage. Nerve fiber damage was observed both proximal and distal area of all sections in 65% obstructed group. Conclusions: Neurological deficit was observed only in 65% group. Impression degree seems to be important in formation of neurological parameter. Changes in nerve fiber structure are observed in slight obstructions. These changes characterized with vacuolization are observed more frequent when the obstruction increases. Also, distal and proximal area of this impression area is effected in severe lumbar stenosis.

Açıklama

Anahtar Kelimeler

Cauda equina, Lumbar spinal stenosis, Rat model

Kaynak

Journal of Neurological Sciences-Turkish

WoS Q Değeri

Q4

Scopus Q Değeri

Cilt

28

Sayı

2

Künye