An investigation of bovine papillomaviruses from ocular squamous cell carcinomas in cattle

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dc.authoridKURU, Mushap/0000-0003-4409-251X
dc.authoridNUHOGLU, HILMI/0000-0003-2530-2542
dc.contributor.authorKarakurt, E.
dc.contributor.authorCoskun, N.
dc.contributor.authorAydin, U.
dc.contributor.authorBeytut, E.
dc.contributor.authorDag, S.
dc.contributor.authorAtaseven, V. S.
dc.contributor.authorYilmaz, V
dc.date.accessioned2024-09-18T20:06:10Z
dc.date.available2024-09-18T20:06:10Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Ocular squamous cell carcinomas (OSCCs) in cattle has been studied for many years, but no definite etiology has been established. Squamous cell carcinomas (SCCs) may occur in different body parts of cattle. Depending on the location, it can cause an economic loss of varying degrees. Aims: The aim of this study was to investigate the causes of OSCCs in the eye region of cattle. Methods: Sixty tumoral masses taken form 60 cattle with proliferation in the eye region that were collected between the years 2012-2022 were used. These cases were admitted to our department for routine diagnosis. The tissues were diagnosed as OSCC using histopathological methods. The presence of bovine papillomavirus (BPV), one of the causative factors, was investigated using immunohistochemical and polymerase chain reaction (PCR). Results: Macroscopically masses were nodular or cauliflower-like and fragile and had hemorrhagic surfaces. Considering the keratin pearls, tumoral islands, and squamous differentiation, 20 out of 60 cases were classified as well, 20 as moderately, and 20 as poorly-differentiated OSCCs. 47 of the 60 cases were BPV positive using immunohistochemical methods. However, BPV nucleic acid was detected in only two cases with PCR. Only one of the cases could be sequenced. After phylogenetic analysis, virus strain was identified as BPV-1. Conclusion: Our results indicated that papillomaviruses can contribute to the development of OSCCs, in both precursor lesions and also advanced stage OSCCs. We found that BPV-1 has a possible causative role; however, more studies are needed to investigate the role of other viral agents and their interaction with secondary factors.en_US
dc.identifier.doi10.22099/IJVR.2022.43152.6282
dc.identifier.endpage57en_US
dc.identifier.issn1728-1997
dc.identifier.issue1en_US
dc.identifier.pmid37378381en_US
dc.identifier.scopus2-s2.0-85167415930en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.22099/IJVR.2022.43152.6282
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8338
dc.identifier.volume24en_US
dc.identifier.wosWOS:001026800900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherShiraz Univen_US
dc.relation.ispartofIranian Journal of Veterinary Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBovine papillomavirusen_US
dc.subjectImmunohistochemistryen_US
dc.subjectOcular squamous cell carcinomaen_US
dc.subjectPCRen_US
dc.titleAn investigation of bovine papillomaviruses from ocular squamous cell carcinomas in cattleen_US
dc.typeArticleen_US

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