Antimicrobial and antioxidant activities of the various extracts of Verbascum pinetorum Boiss. O. Kuntze (Scrophulariaceae)

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dc.authoridColeri Cihan, Arzu/0000-0002-7289-6251
dc.contributor.authorOzcan, B.
dc.contributor.authorEsen, M.
dc.contributor.authorCaliskan, M.
dc.contributor.authorMothana, R. A.
dc.contributor.authorCihan, A. C.
dc.contributor.authorYolcu, H.
dc.date.accessioned2024-09-18T19:54:34Z
dc.date.available2024-09-18T19:54:34Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and Objectives: The present study was performed to evaluate the in vitro antimicrobial and antioxidant properties of various extracts of Verbascum (V.) pinetorum, a member of Scrophulariaceae family. While the antimicrobial activity of various extracts of V. pinetorum was determined with agar-well diffusion method, the antioxidant activity was examined with two complementary test systems, namely 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and beta-carotene/linoleic acid test systems. Results: The hexane extract exhibits antimicrobial activity against few microorganisms. However, dichloromethane, direct methanol and methanol/chloroform extracts are effective on a broad range of microorganisms. Among the tested bacteria Haemophilus influenzae was found to be the most sensitive bacterium. The 50% (IC50) inhibition activity of the methanolic extract of V. pinetorum on the free radical DPPH was determined as 13.04 mg/ml. In the case of the linoleic acid system, oxidation of linoleic acid was inhibited by methanolic extract of V. pinetorum, which showed 89.39% inhibition that is quite close to the value of the synthetic antioxidant reagent butylhydroxytoluene (BHT), 92.46%. Iridoid glycosides, flavonoids and saponins were determined as the major natural compounds in the methanolic extracts. The total phenolic components of V. pinetorum were found as 42.45 mg/g gallic acid equivalent. Conclusion: The results provide evidence that the extracts of V. pinetorum contained iridoid glycosides, flavonoids, saponins and phenolic compounds which may be responsible for the substantial antimicrobial and antioxidant activities.en_US
dc.description.sponsorshipResearch Council of Mustafa Kemal University, Hatay, Turkeyen_US
dc.description.sponsorshipThis research was supported partially by Research Council of Mustafa Kemal University, Hatay, Turkey.en_US
dc.identifier.endpage905en_US
dc.identifier.issn1128-3602
dc.identifier.issue8en_US
dc.identifier.pmid21845800en_US
dc.identifier.scopus2-s2.0-80052369473en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage900en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7801
dc.identifier.volume15en_US
dc.identifier.wosWOS:000293744800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidanten_US
dc.subjectTotal phenolsen_US
dc.subjectVerbascum pinetorumen_US
dc.subjectTurkeyen_US
dc.titleAntimicrobial and antioxidant activities of the various extracts of Verbascum pinetorum Boiss. O. Kuntze (Scrophulariaceae)en_US
dc.typeArticleen_US

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