Serum biomarkers of endothelial glycocalyx injury in canine parvoviral infection

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dc.authoridNASERI, AMIR/0000-0001-9140-5879
dc.authoridDURGUT, MURAT KAAN/0000-0002-4582-8536
dc.authoridGulersoy, Erdem/0000-0001-8511-0150
dc.authoridERTURK, ALPER/0000-0002-4271-7953
dc.contributor.authorNaseri, Amir
dc.contributor.authorGulersoy, Erdem
dc.contributor.authorIder, Merve
dc.contributor.authorDurgut, Murat Kaan
dc.contributor.authorErturk, Alper
dc.contributor.authorAvci, Cagri
dc.contributor.authorKoral, Erman
dc.date.accessioned2024-09-18T21:00:33Z
dc.date.available2024-09-18T21:00:33Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCanine parvoviral enteritis (PVE) is one of the most common diseases in young dogs. A range of diseases and inflammatory conditions can cause endothelial glycocalyx (eGCX) disruption, therefore, this study aimed to determine the presence of eGCX damage in dogs with PVE using serum biomarkers of eGCX. and to evaluate their prognostic importance among survivor and non-survivor dogs. Twenty dogs diagnosed with PVE and 10 healthy dogs of both sexes, mixed-breed, and under 6 months of age were included in the study. Clinical examination, blood gas analysis, and complete blood cell counts of the dogs were performed. To detect the eGCX injury, serum endothelial cell-specific molecule-1 (ESM-1), syndecan-1 (SDC-1), angiopoietin-2 (Ang-2), and heparan sulfate (HS) levels were measured. Results showed that at the time of admission serum levels of ESM-1 were higher in dogs with PVE compared to that of the healthy dogs. Dogs with PVE were further assigned into two groups: survivors (n:10) and non-survivors (n:10). The ESM-1 had high sensitivity and specificity to differentiate between survivor and non-survivor dogs with values of 100% and 67%, respectively, with at an optimum cut-off point of >= 460 pg/mL. We concluded that higher levels of ESM- 1 in dogs with PVE may indicate eGCX injury when compared to healthy dogs. Also, the high levels of serum ESM-1 in non-survivor dogs suggest that serum ESM-1 may carry some prognostic usefulness for predicting mortality in dogs with PVE.en_US
dc.description.sponsorshipSelcuk University Scientific Research Office [19401010]en_US
dc.description.sponsorshipThis study was financially supported by the Selcuk University Scientific Research Office (Project no: 19401010).en_US
dc.identifier.endpage101en_US
dc.identifier.issn0719-8000
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85095760056en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12751
dc.identifier.volume52en_US
dc.identifier.wosWOS:000572177600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Austral Chile, Fac Ciencias Veterinariasen_US
dc.relation.ispartofAustral Journal of Veterinary Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectvascular endotheliumen_US
dc.subjectdogen_US
dc.subjectendothelial cell-specific molecule-1en_US
dc.subjectsepsisen_US
dc.subjectoutcomeen_US
dc.titleSerum biomarkers of endothelial glycocalyx injury in canine parvoviral infectionen_US
dc.typeArticleen_US

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