Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas

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dc.contributor.authorOral, Onur
dc.contributor.authorUnverdi, Hatice
dc.contributor.authorKumcu, Emrah
dc.contributor.authorTurkbey, Duygu
dc.contributor.authorDogan, Serdar
dc.contributor.authorHucumenoglu, Sema
dc.date.accessioned2024-09-18T20:06:12Z
dc.date.available2024-09-18T20:06:12Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAims: The aim of this study is to evaluate the relationships between the expression of mucins in invasive breast carcinomas and clinicopathologic parameters. Materials and Methods: We examined 150 cases of invasive breast carcinoma, using the 2012 World Health Organization (WHO) classification of the tumors of the breast. We studied the expression of MUC1, MUC2, MUC5AC, and MUC6 by immunohistochemistry. We also evaluated normal breast tissue and ductal carcinoma in situ (DCIS) lesions in nearby invasive tumor areas. Results: In invasive breast carcinomas, MUC1, MUC2, MUC5AC, and MUC6 were expressed in 98.6%, 11.3%, 9.9, and 8.5% of cases, respectively. MUC2, MUC5AC, and MUC6 were overexpressed in invasive tumors and DCIS lesions were compared with normal breast tissue. The apical pattern of MUC1 was correlated with low grade and ER expression. MUC2 was correlated with mucinous carcinoma and an inverse association with invasive ductal carcinoma, not otherwise specified (NOS). MUC6 expression was associated with lymphovascular invasion. Conclusions: Most invasive breast tumors express MUC1 and the apical pattern of MUC1 is correlated with low grade and ER expression. MUC6 expression is associated with indicators of poor prognosis. Further comprehensive studies need to evaluate the role of mucins as a potential biomarker and to be used as a specific therapeutic target against breast cancer.en_US
dc.identifier.doi10.4103/IJPM.IJPM_637_18
dc.identifier.endpage558en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.issue4en_US
dc.identifier.pmid33154304en_US
dc.identifier.scopus2-s2.0-85095798069en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage551en_US
dc.identifier.urihttps://doi.org/10.4103/IJPM.IJPM_637_18
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8370
dc.identifier.volume63en_US
dc.identifier.wosWOS:000596485100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Pathology and Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast canceren_US
dc.subjectMUC1en_US
dc.subjectMUC2en_US
dc.subjectMUC5ACen_US
dc.subjectMUC6en_US
dc.subjectprognosisen_US
dc.titleAssociations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomasen_US
dc.typeArticleen_US

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