Pharmacokinetic behaviour and pharmacokinetic-pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations

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dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridBilen, Soner/0000-0001-9459-8178
dc.authoridTerzi, Ertugrul/0000-0003-2811-6497
dc.authoridALTAN, Feray/0000-0002-9017-763X
dc.contributor.authorAltan, Feray
dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorUney, Kamil
dc.contributor.authorTerzi, Ertugrul
dc.contributor.authorBilen, Soner
dc.contributor.authorSonmez, Adem Yavuz
dc.date.accessioned2024-09-18T19:50:25Z
dc.date.available2024-09-18T19:50:25Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Doxycycline (DO) has been used in fish for a long time, but there are some factors that have not yet been clarified regarding its pharmacokinetic (PK) and pharmacodynamic (PD) properties. Therefore, the aim of this study was to investigate the PK and PK/PD targets of DO after 20 mg/kg intravascular (IV), intramuscular (IM) and oral (OR) gavage administration in rainbow trout (Oncorhynchus mykiss). Methods: Plasma samples were collected at specific time points and subsequently analysed by HPLC-ultraviolet. The PK/PD indices were calculated based on the MIC90 (Aeromonas hydrophila and Aeromonas sobria) values obtained for the respective bacteria and the PK parameters obtained for DO following both IM and OR administration. Results: After IV administration, the elimination half-life (t(1/2 lambda z)), area under the concentration vs. time curve (AUC), apparent volume of distribution at steady-state and total body clearance of DO were 34.81 h, 723.82 h mu g/mL, 1.24 L/kg and 0.03 L/kg/h, respectively. The t(1/2 lambda z) of the DO was found to be 37.39 and 39.78 h after IM, and OR administration, respectively. The bioavailability was calculated 57.02% and 32.29%, respectively, after IM and OR administration. The MIC90 of DO against A. hydrophila and A. sobria was 4 mu g/mL. The PK/PD integration showed that DO (20 mg/kg dose) for A. hydrophila and A. sobria with MIC90 <= 4 mu g/mL achieved target AUC/MIC value after IM administration. Conclusions: These results suggest that when rainbow trout was treated with 20 mg/kg IV and IM administered DO, therapeutically effective concentrations were reached in the control of infections caused by A. hydrophila and A. sobria.en_US
dc.description.sponsorshipCoordination of Scientific Research Projects; Coordination of Scientific Research Projects, University of Dicleen_US
dc.description.sponsorshipThis study was supported by the Coordination of Scientific Research Projects, University of Dicle, Turkiye (Project No. VETERINER.19.009).en_US
dc.identifier.doi10.1002/vms3.1419
dc.identifier.issn2053-1095
dc.identifier.issue3en_US
dc.identifier.pmid38520701en_US
dc.identifier.scopus2-s2.0-85188418176en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/vms3.1419
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7433
dc.identifier.volume10en_US
dc.identifier.wosWOS:001189586700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofVeterinary Medicine and Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAeromonas hydrophilaen_US
dc.subjectAeromonas sobriaen_US
dc.subjectdoxycyclineen_US
dc.subjectpharmacokineticsen_US
dc.subjectPK-PD integrationen_US
dc.subjectrainbow trouten_US
dc.titlePharmacokinetic behaviour and pharmacokinetic-pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrationsen_US
dc.typeArticleen_US

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