The effects of caffeic acid phenethyl ester (CAPE) treatment on rheumatologic parameters and iron metabolism in diabetic rats

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dc.authoridAytekin, Ismail/0000-0001-6794-5453
dc.contributor.authorAytekin, Ismail
dc.contributor.authorDevrim, Alparslan K.
dc.contributor.authorOzturk, Aliye S.
dc.contributor.authorAksit, Hasan
dc.contributor.authorMamak, Nuri
dc.contributor.authorHismiogullari, Sahver E.
dc.date.accessioned2024-09-18T20:06:20Z
dc.date.available2024-09-18T20:06:20Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractDiabetology and rheumatology have much in common, including many biochemical features. Diabetic cases suffer excessively from common musculoskeletal conditions. The present study aimed to explore the association between the caffeic acid phenethyl ester (CAPE) treatment and the standard parameters of diabetic and rheumatologic controls. Serum anti-streptolysin-O (ASO), C-reactive protein (CRP), rheumatoid factor (RF) titers and glucose (GLU), cholesterol (CHOL), triglyceride (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), alkaline phosphatase (ALP), gamma-glutamyl transferase (GUT), sodium (Na), potassium (K), chloride (Cl), calcium (Ca), phosphorus (P), uric acid (UA), iron (Fe), iron-binding capacity (IBC), total iron-binding capacity (TIBC) and superoxide dismutase (SOD) levels were measured in 22 female Wistar-Albino rats. The animals were divided into three groups: group 1: non-diabetic rats as control; group 2: streptozotocin (STZ)-induced, untreated diabetic rats; and group 3: STZ-induced, CAPE-treated diabetic rats. Levels of GLU were increased in group 2. ASO values were decreased in group 3. TG and VLDL levels were increased in group 3 compared with the group 1. Higher UA levels were detected in group 3 compared with group 2. The levels of Fe and TIBC were decreased in group 3. The results of the present study indicate the reducing effect of CAPE on the serum levels of diabetic and rheumatologic parameters in diabetic rats.en_US
dc.identifier.endpage473en_US
dc.identifier.issn0372-5480
dc.identifier.issn1331-8055
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84937702146en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage465en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8469
dc.identifier.volume85en_US
dc.identifier.wosWOS:000359750400009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Zagreb Vet Facultyen_US
dc.relation.ispartofVeterinarski Arhiven_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl ester (CAPE)en_US
dc.subjectdiabetesen_US
dc.subjectironen_US
dc.subjectraten_US
dc.subjectrheumatologic parametersen_US
dc.titleThe effects of caffeic acid phenethyl ester (CAPE) treatment on rheumatologic parameters and iron metabolism in diabetic ratsen_US
dc.typeArticleen_US

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