Comparison of the chronic effects of ribavirin and caffeic acid phenethyl ester (CAPE) on pancreatic damage and hepatotoxicity

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dc.contributor.authorMotor, Sedat
dc.contributor.authorAlp, Harun
dc.contributor.authorSenol, Serkan
dc.contributor.authorPinar, Neslihan
dc.contributor.authorMotor, Vicdan Koksaldi
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorAlp, Ayse
dc.date.accessioned2024-09-18T20:06:27Z
dc.date.available2024-09-18T20:06:27Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study was aimed to comparison of the effects of the chronic use of the Ribavirin and caffeic acid phenethyl ester (CAPE) on the pancreatic damage and hepatotoxicity in rats. Methods: The rats were given orally 30 mg/kg/day doses of Ribavirin for 30 days, and intraperitoneally 10 mu mol/kg doses of CAPE. The 37 rats were divided into 4 groups: (I) Control (n=7), (II) Ribavirin (R) (n=10), (III) CAPE (n=10), and (IV) R+CAPE (n=10). Results: Ribavirin and CAPE yielded similar results in terms of Serum, total antioxidant status (TAS), total oxidant status (TOS), amylase, lipase, and insulin compared to the control group. However, while Ribavirin provided similar results with the control group in terms of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes, the CAPE group had elevated AST and ALT levels compared to the control group. Histopathologic evaluations revealed that CAPE or Ribavirin had no degenerative effects on both the pancreas and liver tissues. In this way, the biochemical results were confirmed by the histopathologic results. Conclusion: It can be concluded that Ribavirin does not lead to any pancreatic damage and hepatotoxicity, and has more beneficial effects than CAPE on especially liver tissue.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Project Coordination [1206 M 0124 (395)]en_US
dc.description.sponsorshipThis study with 1206 M 0124 (395) number was supported by Mustafa Kemal University Scientific Research Project Coordination.en_US
dc.identifier.endpage1013en_US
dc.identifier.issn1940-5901
dc.identifier.issue4en_US
dc.identifier.pmid24955174en_US
dc.identifier.scopus2-s2.0-84900411591en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1005en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8526
dc.identifier.volume7en_US
dc.identifier.wosWOS:000336740600027en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCAPEen_US
dc.subjectribavirinen_US
dc.subjectinsulinen_US
dc.subjecthepatotoxicityen_US
dc.subjectpancreatic damageen_US
dc.subjectoxidative stressen_US
dc.titleComparison of the chronic effects of ribavirin and caffeic acid phenethyl ester (CAPE) on pancreatic damage and hepatotoxicityen_US
dc.typeArticleen_US

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