Adverse effects of oxytetracycline and enrofloxacin on the fertility of Saanen bucks

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dc.authoridmercan yucel, ufuk/0000-0001-8256-7868
dc.authoridKosal, Volkan/0000-0001-5268-5046
dc.authoridUSLU, Baris Atalay/0000-0003-1866-932X
dc.contributor.authorYucel, Ufuk Mercan
dc.contributor.authorKosal, Volkan
dc.contributor.authorKara, Mikail
dc.contributor.authorTaspinar, Filiz
dc.contributor.authorUslu, Baris Atalay
dc.date.accessioned2024-09-18T20:53:03Z
dc.date.available2024-09-18T20:53:03Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study aimed to determine the adverse effects of oxytetracycline and enrofloxacin application on the fertility of Saanen bucks. For this purpose, twenty-four bucks were divided into three groups. Group I (control group) received only 5 ml of 0.9% NaCl for 7 days, group II was given a single dose of 20 mg/kg oxytetracycline and group III was given at a dose of 2.5 mg/kg per day for 7 days intramuscularly. Serum and semen samples were collected from the bucks at post-treatment 1, 3, 5, 7, and 9 days and examined spermatological parameters (quantity, motility, density, abnormal sperm ratio, and live-dead sperm ratio), serum testosterone levels (with ELISA) and sperm DNA parameters (with Comet assay). The results showed no change in sperm volume, abnormal sperm rate, and dead-live sperm ratio in group II and III following oxytetracycline and enrofloxacin administration. However, a decrease in sperm density, sperm motility, mass activity, and testosterone levels, and an increase in sperm DNA damage were detected. These spermatological parameters (density, motility, mass activity) and testosterone levels were less decreased and sperm DNA damage was less increased in group II than group III. The greater damage in group III may be attributed to the longer duration of enrofloxacin administration compared to oxytetracycline and the effect of enrofloxacin on DNA. The results obtained from this study suggest that usage of oxytetracycline and especially enrofloxacin should be restricted and antibiotics with fewer side effects on sperm should be preferred in Saanen bucks during the reproduction period.en_US
dc.identifier.doi10.1007/s11250-021-02898-7
dc.identifier.issn0049-4747
dc.identifier.issn1573-7438
dc.identifier.issue5en_US
dc.identifier.pmid34546445en_US
dc.identifier.scopus2-s2.0-85115216534en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s11250-021-02898-7
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11558
dc.identifier.volume53en_US
dc.identifier.wosWOS:000698422200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofTropical Animal Health and Productionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxytetracyclineen_US
dc.subjectEnrofloxacinen_US
dc.subjectSaanen bucken_US
dc.subjectSperm DNA damageen_US
dc.subjectSpermatological parametersen_US
dc.subjectTestosteroneen_US
dc.titleAdverse effects of oxytetracycline and enrofloxacin on the fertility of Saanen bucksen_US
dc.typeArticleen_US

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