Effects of ebselen on radiocontrast media-induced hepatotoxicity in rats

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dc.authoridUlutas, Kemal Turker/0000-0003-2852-0449
dc.contributor.authorBasarslan, Fatmagul
dc.contributor.authorYilmaz, Nigar
dc.contributor.authorDavarci, Isil
dc.contributor.authorAkin, Mustafa
dc.contributor.authorOzgur, Mustafa
dc.contributor.authorYilmaz, Cahide
dc.contributor.authorUlutas, Kemal Turker
dc.date.accessioned2024-09-18T20:55:37Z
dc.date.available2024-09-18T20:55:37Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOxidative stress is accepted as a potential responsible mechanism in the pathogenesis of radiocontrast media (RCM)-induced hepatotoxicity. Therefore, we aimed to investigate the protective effects of ebselen against RCM-induced hepatotoxicity by measuring tissue oxidant/antioxidant parameters and histological changes in rats. Wistar albino rats were randomly separated into four groups consisting of eight rats per group. Normal saline was given to the rats in control group (group 1). RCM was given to the rats in group 2, and both RCM and ebselen were given to the rats in group 3. Only ebselen was given to the rats in group 4. Liver sections of the killed animals were analyzed to measure the levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), as well as histopathological changes. In RCM group, SOD and CAT levels were found increased. In RCM-ebselen group, MDA, SOD and CAT levels were found decreased. In RCM-ebselen group, however, GSH-Px activities of liver tissue increased. All these results indicated that ebselen produced a protective mechanism against RCM-induced hepatotoxicity and took part in oxidative stress.en_US
dc.identifier.doi10.1177/0748233712442730
dc.identifier.endpage752en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue8en_US
dc.identifier.pmid22491720en_US
dc.identifier.scopus2-s2.0-84883576945en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage746en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712442730
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11960
dc.identifier.volume29en_US
dc.identifier.wosWOS:000323895300010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiocontrast mediaen_US
dc.subjectebselenen_US
dc.subjecthepatotoxicityen_US
dc.subjectoxidative stressen_US
dc.subjectmalondialdehydeen_US
dc.titleEffects of ebselen on radiocontrast media-induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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