Effects of propylene glycol used at different doses in Akkaraman lambs rations on metabolism-related parameters and liver gene and protein expression during different feeding periods
dc.authorid | Unal, Necmettin/0000-0002-9440-7893 | |
dc.authorid | Kaya, Ufuk/0000-0002-4805-0993 | |
dc.authorid | UNAL, NECMETTIN/0000-0001-5250-7063 | |
dc.authorid | Ozkan, Huseyin/0000-0001-5753-8985 | |
dc.contributor.author | Yakan, Akin | |
dc.contributor.author | Ozkan, Huseyin | |
dc.contributor.author | Kaya, Ufuk | |
dc.contributor.author | Keceli, Hasan Huseyin | |
dc.contributor.author | Dalkiran, Sevda | |
dc.contributor.author | Karaaslan, Irem | |
dc.contributor.author | Unal, Necmettin | |
dc.date.accessioned | 2024-09-18T20:25:18Z | |
dc.date.available | 2024-09-18T20:25:18Z | |
dc.date.issued | 2023 | |
dc.department | Hatay Mustafa Kemal Üniversitesi | en_US |
dc.description.abstract | This study aimed to investigate the metabolic effects of propylene glycol (PG) over 60, 90, and 120 days in lambs. Seventy-two weaned male lambs were allocated into three groups: control (Con), PG1.5 (1.5 mL/kg live weight0.75), and PG3 (3 mL/kg live weight0.75). Blood samples were collected at the beginning and slaughter days. Biochemical parameters (glucose, triglycerides, ALT, AST, LDH, BUN, and insulin) and gene and protein levels of peroxisome proliferator activated receptor gamma (PPAR gamma), diacylglycerol o-acyltransferase 1 (DGAT1), carbohydrate responsive element binding protein (ChREBP), and sterol regulatory element binding transcription factor 1c (SREBP-1c) in the liver were determined. Glucose in PG1.5 was increased on Day 60, while significant differences were observed in biochemical parameters except for insulin on the 60, 90, and 120 days. Biochemical parameters such as ALT, AST, LDH, and BUN increased over time, while triglycerides decreased. DGAT1 gene and protein levels were lower, while SREBP-1c and PPAR gamma were higher in PG groups on Day 60. While SREBP-1c was lower in PG1.5, ChREBP was higher in PG3 on Day 90. PPAR gamma, DGAT1, and ChREBP were upregulated in PG3 on Day 120. Positive correlations were found between proteins. The long-term use of PG in lambs did not have detrimental effects on metabolism. The study provides valuable insights into the molecular mechanisms underlying the metabolic effects of PG in lambs, shedding light on its potential applications in lamb production. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkiye (TUBIdot;TAK) [119R076] | en_US |
dc.description.sponsorship | This study was financially supported by the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK) with a 119R076 project number. | en_US |
dc.identifier.doi | 10.1111/asj.13886 | |
dc.identifier.issn | 1344-3941 | |
dc.identifier.issn | 1740-0929 | |
dc.identifier.issue | 1 | en_US |
dc.identifier.pmid | 37963598 | en_US |
dc.identifier.scopus | 2-s2.0-85176582443 | en_US |
dc.identifier.scopusquality | Q1 | en_US |
dc.identifier.uri | https://doi.org/10.1111/asj.13886 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12483/10232 | |
dc.identifier.volume | 94 | en_US |
dc.identifier.wos | WOS:001101879800001 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | Animal Science Journal | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | gene expression | en_US |
dc.subject | lamb ration | en_US |
dc.subject | metabolism | en_US |
dc.subject | propylene glycol | en_US |
dc.subject | protein expression | en_US |
dc.title | Effects of propylene glycol used at different doses in Akkaraman lambs rations on metabolism-related parameters and liver gene and protein expression during different feeding periods | en_US |
dc.type | Article | en_US |