Effects of propylene glycol used at different doses in Akkaraman lambs rations on metabolism-related parameters and liver gene and protein expression during different feeding periods

dc.authoridUnal, Necmettin/0000-0002-9440-7893
dc.authoridKaya, Ufuk/0000-0002-4805-0993
dc.authoridUNAL, NECMETTIN/0000-0001-5250-7063
dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.contributor.authorYakan, Akin
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorKaya, Ufuk
dc.contributor.authorKeceli, Hasan Huseyin
dc.contributor.authorDalkiran, Sevda
dc.contributor.authorKaraaslan, Irem
dc.contributor.authorUnal, Necmettin
dc.date.accessioned2024-09-18T20:25:18Z
dc.date.available2024-09-18T20:25:18Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study aimed to investigate the metabolic effects of propylene glycol (PG) over 60, 90, and 120 days in lambs. Seventy-two weaned male lambs were allocated into three groups: control (Con), PG1.5 (1.5 mL/kg live weight0.75), and PG3 (3 mL/kg live weight0.75). Blood samples were collected at the beginning and slaughter days. Biochemical parameters (glucose, triglycerides, ALT, AST, LDH, BUN, and insulin) and gene and protein levels of peroxisome proliferator activated receptor gamma (PPAR gamma), diacylglycerol o-acyltransferase 1 (DGAT1), carbohydrate responsive element binding protein (ChREBP), and sterol regulatory element binding transcription factor 1c (SREBP-1c) in the liver were determined. Glucose in PG1.5 was increased on Day 60, while significant differences were observed in biochemical parameters except for insulin on the 60, 90, and 120 days. Biochemical parameters such as ALT, AST, LDH, and BUN increased over time, while triglycerides decreased. DGAT1 gene and protein levels were lower, while SREBP-1c and PPAR gamma were higher in PG groups on Day 60. While SREBP-1c was lower in PG1.5, ChREBP was higher in PG3 on Day 90. PPAR gamma, DGAT1, and ChREBP were upregulated in PG3 on Day 120. Positive correlations were found between proteins. The long-term use of PG in lambs did not have detrimental effects on metabolism. The study provides valuable insights into the molecular mechanisms underlying the metabolic effects of PG in lambs, shedding light on its potential applications in lamb production.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBIdot;TAK) [119R076]en_US
dc.description.sponsorshipThis study was financially supported by the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK) with a 119R076 project number.en_US
dc.identifier.doi10.1111/asj.13886
dc.identifier.issn1344-3941
dc.identifier.issn1740-0929
dc.identifier.issue1en_US
dc.identifier.pmid37963598en_US
dc.identifier.scopus2-s2.0-85176582443en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/asj.13886
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10232
dc.identifier.volume94en_US
dc.identifier.wosWOS:001101879800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAnimal Science Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgene expressionen_US
dc.subjectlamb rationen_US
dc.subjectmetabolismen_US
dc.subjectpropylene glycolen_US
dc.subjectprotein expressionen_US
dc.titleEffects of propylene glycol used at different doses in Akkaraman lambs rations on metabolism-related parameters and liver gene and protein expression during different feeding periodsen_US
dc.typeArticleen_US

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