The Importance of Demodex Mites (Acari: Demodicidae) in Patients With Sickle Cell Anemia

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dc.authoridMumcuoglu, Kosta Y./0000-0001-8125-6099
dc.contributor.authorKaya, Ozlem Aycan
dc.contributor.authorAkkucuk, Serife
dc.contributor.authorIlhan, Gul
dc.contributor.authorGuneri, Cansu Onlen
dc.contributor.authorMumcuoglu, Kosta
dc.date.accessioned2024-09-18T20:57:00Z
dc.date.available2024-09-18T20:57:00Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAlthough demodicosis caused by Demodex folliculorum and Demodex brevis is widely seen throughout the world, the pathogenic mechanisms are not fully known. To the best of our knowledge, the effect of Demodex mites in patients with sickle cell anemia (SCA) is not known. SCA is a genetic disease characterized by abnormal hemoglobin production and suppression of the immune system. The aim of this study was to determine the prevalence and Demodex density in SCA patients and to compare with healthy subjects. The study included 70 patients diagnosed with SCA and control group of 50 healthy individuals. Samples were taken from cheeks, forehead, nose, and chin and were examined microscopically. Infestation of >= 5 mites/cm(2) was accepted as positive in the diagnosis. Demodex mite positivity was determined in 20 (28.6%) patients and none in subjects of the control group. In the SCA group, the mean number of mites was 26.10/cm(2). A statistically significant correlation was found between Demodex mite positivity and the number of SCA symptom attacks experienced by the patients within the last 1 yr (P <= 0.001). No significant relationship was determined between Demodex mite positivity and age or gender (P = 0.56 and P = 0.11, respectively). Demodex mites are seen more often in SCA patients who suffer from a compromised immune system, and the presence of Demodex mites could be a risk factor in the appearance of SCA symptom attacks.en_US
dc.identifier.doi10.1093/jme/tjy225
dc.identifier.endpage602en_US
dc.identifier.issn0022-2585
dc.identifier.issn1938-2928
dc.identifier.issue3en_US
dc.identifier.pmid30576478en_US
dc.identifier.scopus2-s2.0-85064991375en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage599en_US
dc.identifier.urihttps://doi.org/10.1093/jme/tjy225
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12231
dc.identifier.volume56en_US
dc.identifier.wosWOS:000482879500002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofJournal of Medical Entomologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSickle cell anemiaen_US
dc.subjectDemodex mitesen_US
dc.subjectprevalenceen_US
dc.subjectintensity of infestationen_US
dc.titleThe Importance of Demodex Mites (Acari: Demodicidae) in Patients With Sickle Cell Anemiaen_US
dc.typeArticleen_US

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