Subacute toxicity of piperonyl butoxide and resmethrin in mice
[ N/A ]
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Academic Journals
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The subacute toxic effects of separate and combined use of piperonyl butoxide and resmethrin (cismethrin) on the liver and kidneys of male mice were investigated. It is known that when given alone, pyrethroids are toxic and their toxicity becomes more complicated when they are co-formulated with piperonyl butoxide. In the present study, macroscopic and microscopic changes were determined in the liver and kidney tissues. Furthermore, biochemical alterations and clinical neurotoxic effects were observed. Toxic effects were more evident in the group subjected to combined use. The results obtained demonstrated that, in mice, piperonyl butoxide and resmethrin are directly toxic to the liver and kidneys. The toxic effects and tissue degeneration were more widespread in the group subjected to combined use.
Açıklama
Anahtar Kelimeler
Piperonyl butoxide, resmethrin, sub-acute toxicity, histopathology, liver, kidney
Kaynak
African Journal of Pharmacy and Pharmacology
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
6
Sayı
27
