Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats

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dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.contributor.authorOktar, S.
dc.contributor.authorYonden, Z.
dc.contributor.authorAydin, M.
dc.contributor.authorIlhan, S.
dc.contributor.authorAlcin, E.
dc.contributor.authorOzturk, O. H.
dc.date.accessioned2024-09-18T20:06:21Z
dc.date.available2024-09-18T20:06:21Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractS. OKTAR, Z. YONDEN, M. AYDIN, S. ILHAN, E. ALCIN and O.H. OZTURK. Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats. J Physiol Biochem, 65 (4), 339-344, 2009. Caffeic acid phenethyl ester (CAPE) is a natural product with potent anti-inflammatory, antitumor, and antioxidant activities, and attenuates inflammation and lipid peroxidation. The purpose of the present study was to investigate the effects of CAPE on iron-induced liver damage. Rats were divided into four groups and treated for 7 days with saline (control group), 10 mu mol kg CAPE/day s.c. (CAPE group), 50 mg iron-dextran/kg i.p. (IRON group) and CAPE and iron at the same time (IRON+CAPE group). Seven days later, rats were killed and the livers were excised for biochemical analysis. The administration of IRON alone resulted in higher myeloperoxidase (MPO) activity and lipid peroxidation than in the control and CAPE treatment prevented the increase in MPO activity and malondialdeyde (MDA) level. No differences were observed in all four groups with regards to superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. Our results collectively suggest that CAPE may be an available agent to protect the liver from injury via inhibition of MPO activity.en_US
dc.identifier.doi10.1007/BF03185928
dc.identifier.endpage344en_US
dc.identifier.issn1138-7548
dc.identifier.issn1877-8755
dc.identifier.issue4en_US
dc.identifier.pmid20358346en_US
dc.identifier.startpage339en_US
dc.identifier.urihttps://doi.org/10.1007/BF03185928
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8473
dc.identifier.volume65en_US
dc.identifier.wosWOS:000276442600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectIron overloaden_US
dc.subjectMyeloperoxidaseen_US
dc.subjectMalondialdehydeen_US
dc.subjectOxidative stressen_US
dc.subjectLiveren_US
dc.titleProtective effects of caffeic acid phenethyl ester on iron-induced liver damage in ratsen_US
dc.typeArticleen_US

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