Investigating the Levels of Brain-Specific Proteins in Hydrocephalus Patients

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dc.authoridGUZELCICEK, AHMET/0000-0002-9733-3957
dc.authoridKaradag, Mehmet/0000-0001-9539-4193
dc.authoridCADIRCI BARUT, DURSUN/0000-0003-0969-382X
dc.contributor.authorGuzelcicek, Ahmet
dc.contributor.authorGonel, Ataman
dc.contributor.authorKoyuncu, Ismail
dc.contributor.authorCigdem, Gulyara
dc.contributor.authorKose, Dogan
dc.contributor.authorKaradag, Mehmet
dc.contributor.authorCadirci, Dursun
dc.date.accessioned2024-09-18T20:52:48Z
dc.date.available2024-09-18T20:52:48Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Hydrocephalus, a common brain disorder in children, can cause permanent brain damage. A timely diagnosis of this disorder is crucial. Objective: The aim of this study was to evaluate the levels of S-100, CK-18, and NSE brain-specific proteins in patients with hydrocephalus. We examined the levels of these proteins in the blood samples of hydrocephalic patients. Methods: The study was conducted on the hydrocephalus (n = 31) patients and a healthy control group (n = 30). A Receiver Operating Characteristic (ROC) curve was used to assess the validity of the NSE, CK-18, and S100B to differentiate between the hydrocephalus and the control groups. The suitability of the data to the normal distribution was tested with the Shapiro Wilk test, and the Student t-test was used to compare the characteristics of the normal distribution in two independent groups. The individuals in the hydrocephalus and control groups had similar values in terms of age, height, and weight. Results: It was observed that NSE, CK-18, and S100B mean values of the individuals in the hydrocephalus group were significantly higher than NSE, CK-18, and S100B mean values of the control group. Conclusion: Experiments have shown that the levels of these proteins increase significantly in hydrocephalus patients compared to the healthy group. These three parameters can be considered as important markers in the diagnosis of hydrocephalus.en_US
dc.identifier.doi10.2174/1386207323666200720093245
dc.identifier.endpage414en_US
dc.identifier.issn1386-2073
dc.identifier.issn1875-5402
dc.identifier.issue3en_US
dc.identifier.pmid32691706en_US
dc.identifier.scopus2-s2.0-85102218723en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage409en_US
dc.identifier.urihttps://doi.org/10.2174/1386207323666200720093245
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11411
dc.identifier.volume24en_US
dc.identifier.wosWOS:000642209800009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCombinatorial Chemistry & High Throughput Screeningen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNSEen_US
dc.subjectCK-18en_US
dc.subjectS100Ben_US
dc.subjecthydrocephalusen_US
dc.subjectdiagnosisen_US
dc.subjectchildhooden_US
dc.titleInvestigating the Levels of Brain-Specific Proteins in Hydrocephalus Patientsen_US
dc.typeArticleen_US

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