Demarcating the gene-rich regions of the wheat genome
[ N/A ]
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
By physically mapping 3025 loci including 252 phenotypically characterized genes and 17 quantitative trait loci (QTLs) relative to 334 deletion breakpoints, we localized the gene-containing fraction to 29% of the wheat genome present as 18 major and 30 minor gene-rich regions (GRRs). The GRRs varied both in gene number and density. The five largest GRRs physically spanning <3% of the genome contained 26% of the wheat genes. Approximate size of the GRRs ranged from 3 to 71 Mb. Recombination mainly occurred in the GRRs. Various GRRs varied as much as 128-fold for gene density and 140-fold for recombination rates. Except for a general suppression in 25-40% of the chromosomal region around centromeres, no correlation of recombination was observed with the gene density, the size, or chromosomal location of GRRs. More than 30% of the wheat genes are in recombination-poor regions thus are inaccessible to map-based cloning. © Oxford University Press 2004; all rights reserved.
Açıklama
Anahtar Kelimeler
Chromosome Mapping, DNA, Plant, Genes, Plant, Genetic Markers, Genome, Plant, Phenotype, Physical Chromosome Mapping, Quantitative Trait Loci, Recombination, Genetic, Triticum, Triticum aestivum, plant DNA, plant DNA, article, centromere, controlled study, correlation analysis, density, DNA determination, gene deletion, gene location, gene locus, gene mapping, gene number, gene repression, genetic analysis, genetic recombination, molecular cloning, nonhuman, phenotype, plant genetics, priority journal, quantitative trait locus mapping, restriction fragment length polymorphism, wheat, chromosome map, gene, genetic marker, genetics, genome, quantitative trait locus, wheat
Kaynak
Nucleic Acids Research
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
32
Sayı
12
