Genomic and phylogenetic characterization of ChPV2, a novel goat PV closely related to the Xi-PV1 species infecting bovines

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dc.authoridBravo, Ignacio G./0000-0003-3389-3389
dc.authoridEhrke-Schulz, Eric/0000-0001-8154-9860
dc.authoridWillemsen, Anouk/0000-0002-8511-3244
dc.authoridEhrhardt, Anja/0000-0002-6639-4888
dc.contributor.authorWillemsen, Anouk
dc.contributor.authorvan den Boom, Alexander
dc.contributor.authorDietz, Julienne
dc.contributor.authorBilge Dagalp, Seval
dc.contributor.authorDogan, Firat
dc.contributor.authorBravo, Ignacio G.
dc.contributor.authorEhrhardt, Anja
dc.date.accessioned2024-09-18T20:52:48Z
dc.date.available2024-09-18T20:52:48Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Papillomaviruses (PVs) infecting artiodactyls are very diverse, and only second in number to PVs infecting primates. PVs associated to lesions in economically important ruminant species have been isolated from cattle and sheep. Methods Potential PV DNA from teat lesions of a Damascus goat was isolated, cloned and sequenced. The PV genome was analyzed using bioinformatics approaches to detect open reading frames and to predict potential features of encoded proteins as well as putative regulatory elements. Sequence comparison and phylogenetic analyses using the concatenated E1E2L2L1 nucleotide and amino acid alignments was used to reveal the relationship of the new PV to the known PV diversity and its closest relevants. Results We isolated and characterized the full-genome of novel Capra hircus papillomavirus. We identified the E6, E7, E1, E2, L2, L1 open reading frames with protein coding potential and putative active elements in the ChPV2 proteins and putative regulatory genome elements. Sequence similarities of L1 and phylogenetic analyses using concatenated E1E2L2L1 nucleotide and amino acid alignments suggest the classification as a new PV type designated ChPV2 with a phylogenetic position within the XiPV genus, basal to the XiPV1 species. ChPV2 is not closely related to ChPV1, the other known goat PV isolated from healthy skin, although both of them belong confidently into a clade composed of PVs infecting cervids and bovids. Interestingly, ChPV2 contains an E6 open reading frame whereas all closely related PVs do not Conclusion ChPV2 is a novel goat PV closely related to the Xi-PV1 species infecting bovines. Phylogenetic relationships and genome architecture of ChPV2 and closely related PV types suggest at least two independent E6 losses within the XiPV clade.en_US
dc.description.sponsorshipProjekt DEAL; Alexander Karl-Preis 2018 from the Stiftung Tumorforschung Kopf-Hals; European Union Horizon 2020 Marie Sklodowska-Curie research and innovation program grant ONCOGENEVOL [750180]; Marie Curie Actions (MSCA) [750180] Funding Source: Marie Curie Actions (MSCA)en_US
dc.description.sponsorshipOpen Access funding enabled and organized by Projekt DEAL. Funding was provided to Eric Ehrke-Schulz by the Alexander Karl-Preis 2018 from the Stiftung Tumorforschung Kopf-Hals. AW was supported by the European Union Horizon 2020 Marie Sklodowska-Curie research and innovation program grant ONCOGENEVOL (Contract Number 750180).en_US
dc.identifier.doi10.1186/s12985-020-01440-9
dc.identifier.issn1743-422X
dc.identifier.issue1en_US
dc.identifier.pmid33126890en_US
dc.identifier.scopus2-s2.0-85094678143en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s12985-020-01440-9
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11409
dc.identifier.volume17en_US
dc.identifier.wosWOS:000583056700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofVirology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNovel goat papillomavirusen_US
dc.subjectChPV2en_US
dc.subjectGenome characterizationen_US
dc.subjectPhylogenetic analysisen_US
dc.titleGenomic and phylogenetic characterization of ChPV2, a novel goat PV closely related to the Xi-PV1 species infecting bovinesen_US
dc.typeArticleen_US

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