Red blood cell oxidant/antioxidant status in patients with lung cancer and pneumonia

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dc.authorscopusid6701831814
dc.authorscopusid6508066097
dc.authorscopusid6602542598
dc.authorscopusid55854278100
dc.authorscopusid6701808364
dc.authorscopusid7006625363
dc.contributor.authorÖzyurt, Hüseyin
dc.contributor.authorGökbulut, Incilay
dc.contributor.authorÖzu?urlu, Fikret
dc.contributor.authorKöksal, Nurhan
dc.contributor.authorSö?üt, Sadik
dc.contributor.authorAkyol, Ömer
dc.date.accessioned2024-09-19T15:45:27Z
dc.date.available2024-09-19T15:45:27Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the activities of antioxidant enzymes and the levels of nitric oxide (NO) and malondialdehyde (MDA) in erythrocytes of patients with lung cancer and pneumonia. Erythrocyte superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities as well as MDA and NO levels were measured spectrophotometrically in patients with lung cancer (n=15) and pneumonia (n=12) as well as healthy control subjects (n=14). Erythrocyte CAT and GSH-Px activities were found to be decreased in patients with lung cancer compared with pneumonia and control groups (p<0.0001). It was shown that there was an increase in SOD activity in patients with pneumonia compared to lung cancer (18%) and control groups (15%), but the difference was not statistically significant. Significant correlations were found between MDA and SOD (r=0.796, p<0.0001); between NO and SOD (r=0.759, p<0.001); and between SOD and CAT (r=-0.543, p<0.037) in the lung cancer group. These results suggest insufficient antioxidant enzyme activities in erythrocytes of patients with lung cancer that leads to increased oxidative stress and damage to vital cellular components such as DNA with malignant changes. Erythrocytes may reflect the oxidant/antioxidant changes in lung cancer. Results have shown positive correlations between erythrocyte NO and SOD, and MDA and SOD in both lung cancer and control groups.en_US
dc.identifier.endpage192en_US
dc.identifier.issn1301-8825
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-13244253810en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage185en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14693
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTHOD - Turk Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatalaseen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectLung canceren_US
dc.subjectMalondialdehydeen_US
dc.subjectNitric oxideen_US
dc.subjectPneumoniaen_US
dc.subjectSuperoxide dismutaseen_US
dc.titleRed blood cell oxidant/antioxidant status in patients with lung cancer and pneumoniaen_US
dc.typeConference Objecten_US

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