YKL-40 expression in abnormal invasive placenta cases

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dc.contributor.authorGozukara, Ilay
dc.contributor.authorOzgur, Tumay
dc.contributor.authorDolapcioglu, Kenan
dc.contributor.authorGungoren, Arif
dc.contributor.authorKarapinar, Oya Soylu
dc.date.accessioned2024-09-18T20:27:57Z
dc.date.available2024-09-18T20:27:57Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: YKL-40 is a secreted glycoprotein and has been implicated in the proliferation and differentiation of malignant cells, extracellular tissue remodelling, neovascularisation, inhibition of cancer cell apoptosis and stimulation of tumour-associated fibroblasts. The purpose of this study was to evaluate YKL-40 tissue expression in extravillous trophoblast invasion and its possible implication in placenta creta. Methods: A total of 35 placenta creta cases and six control cases were included in the study, of which eight cases were placenta accreta, 12 were increta and 15 were percreta. Histological YKL-40 staining was scored in tissue as weak (1), medium (2) and strong (3). Results: YKL-40 immunoreactivity intensity in the percreta group was significantly higher compared to the increta and accreta groups (2.47 +/- 0.74, 1.33 +/- 0.49 and 1.37 +/- 0.52, respectively; P = 0.000). YKL-40 immunoreactivity intensity was positively correlated with creta (r = 0.6; P = 0.000), depth of invasion (r = 0.49; P = 0.003) and depth of invasion to full thickness ratio (r = 0.58; P = 0.000). Conclusion: This study demonstrated that YKL-40 is strongly expressed in placenta percreta and is correlated with extravillous trophoblast invasion. These findings may be informative for understanding the pathophysiology of placenta creta.en_US
dc.description.sponsorshipDepartment of Scientific Research Project's in Mustafa Kemal Universityen_US
dc.description.sponsorshipThe Department of Scientific Research Project's in Mustafa Kemal University supported this work.en_US
dc.identifier.doi10.1515/jpm-2016-0208
dc.identifier.endpage575en_US
dc.identifier.issn0300-5577
dc.identifier.issn1619-3997
dc.identifier.issue5en_US
dc.identifier.pmid27977409en_US
dc.identifier.scopus2-s2.0-85023159192en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage571en_US
dc.identifier.urihttps://doi.org/10.1515/jpm-2016-0208
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10639
dc.identifier.volume45en_US
dc.identifier.wosWOS:000405328600008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Perinatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunoreactivityen_US
dc.subjectplacenta cretaen_US
dc.subjecttrophoblasten_US
dc.subjectYKL-40en_US
dc.titleYKL-40 expression in abnormal invasive placenta casesen_US
dc.typeArticleen_US

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